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TranscriptomicsTranscription profiling by array of human estrogen receptor alpha positive breast tumors with and without PIK3CA mutations.
PI3K/AKT pathway plays one of pivotal roles in breast cancer development and maintenance. PIK3CA, coding PIK3 catalytic subunit, is the oncogene which shows the high frequency of gain-of-function mutations leading to the PI3K/AKT pathway activation in breast cancer. In particular in the ERα-positive...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-22035 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of response to tamoxifen in human ERa-positive postmenopausal breast tumor patients
Identification of HRPAP20 and TIMELESS as outstanding candidate markers to predict the response to tamoxifen in ERa-positive postmenopausal breast tumor patients
ORGANISM(S): Homo sapiens 
2007-10-09 | E-TABM-72 | biostudies-arrayexpress
TranscriptomicsSplicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness
Both epigenetic and splicing regulation contribute to tumor progression, but the potential links between these two levels of gene-expression regulation in pathogenesis are not well understood. Here, we report that the mouse and human RNA helicases ddx17 and ddx5 contribute to tumor-cell invasiveness...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-40737 | biostudies-arrayexpress
GenomicsMELARISK_SNP_MITF_geno
Genotypes at MITF E318K variant
EGAD00000000122 | EGA
GenomicsMELARISK_MITF_geno
Genotypes at MITF E318K variant
EGAD00000000121 | EGA
GenomicsA MITF germline mutation predisposes to melanoma and renal cell carcinoma
Study EGAS00000000048
EGAS00000000048 | EGA
GenomicsMELARISK Data Access Committee
Access to data generated by the MELARISK is available by emailing application to the data access committee and will be granted to qualified investigators for appropriate use.
EGAC00000000016 | EGA
TranscriptomicsIGR_MITF_STUDY_BBRB
A recent study of the characteristics of coexisting melanoma and renal cell carcinoma RCC in the same patients supports a genetic predisposition underlying the association between these two cancers. The microphthalmia associated transcription factor (MITF) was proposed to act as a melanoma oncogene;...
ORGANISM(S): Homo sapiens 
2011-09-03 | E-TABM-1198 | biostudies-arrayexpress
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