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TranscriptomicsRNA-seq of effect of Lysophosphatidic acid in ovarian cancer cell line OVCAR8 and macrophage-like cell line THP-1
Ovarian carcinoma (OVCAR8) and macrophage-like cells (THP-1) were treated with LPAs to study their gene expression response.
ORGANISM(S): Homo sapiens 
2019-08-01 | E-MTAB-7113 | biostudies-arrayexpress
TranscriptomicsA PPARbeta/delta-independent lineage shift triggered by the inverse agonist DG172 promotes GM-CSF/IL-4-induced dendritic cell differentiation
The effect of PPARbeta/delta agonists and inverse agonists on GM-CFS/IL-4 induced differentiation of bone marrow derived cells was characterized by transcriptional profiling via micro array.
ORGANISM(S): Mus musculus 
2015-06-03 | E-MTAB-2628 | biostudies-arrayexpress
ProteomicsIdentification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OCMI91s ovarian cancer cells
Elevated levels of lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high grade serous cancer (HGSC) and are associated with a short relapse-free survival. LPA is known to support the metastatic spread of cancer cells by activating a multitude of signaling pathways through G-p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-25 | MSV000091146 | MassIVE
ProteomicsIdentification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OVCAR8 ovarian cancer cells
Elevated levels of lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high grade serous cancer (HGSC) and are associated with a short relapse-free survival. LPA is known to support the metastatic spread of cancer cells by activating a multitude of signaling pathways through G-p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-26 | MSV000091158 | MassIVE
GenomicsDeregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - ChIPseq
PPARD and RXR genome wide binding in tumor associated macrophages from serous ovarian carcinoma was characterized.
ORGANISM(S): Homo sapiens 
2015-06-01 | E-MTAB-3166 | biostudies-arrayexpress
TranscriptomicsDeregulation of PPAR-beta/delta target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - RNAseq
The transcriptome of serous ovarian cancer tumor associated macrophages was characterized. Additionally, their transcription response to PPARD agonists and inverse agonists in cell culture was analyzed.
ORGANISM(S): Homo sapiens 
2015-05-31 | E-MTAB-3167 | biostudies-arrayexpress
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