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TranscriptomicsSNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts
Preimplantation genetic diagnosis (PGD) of aneuploidy by fluorescence in situ hybridisation (FISH) has not delivered the expected clinical benefit. Many previous re-analysis studies of embryos deemed aneuploid by FISH on day 3 have found a high degree of chromosomal normalcy at the blastocyst stage...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-18932 | biostudies-arrayexpress
TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
ProteomicsNative Taylor/Non-Taylor Dispersion – Mass Spectrometry (TNT-MS) Allows Rapid Protein Desalting and Multiplexed, Label-Free Ligand Screening
Native mass spectrometry (MS) has become an important technique in several fields including structural biology and drug discovery, due to its ability to study non-covalent assemblies in the gas phase. In many settings, the main drawbacks of native MS are the incompatibility of electrospray ionisa...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Mus musculus (Mouse) 
2025-07-10 | PXD063440 | Pride
Ligand screening Native ms Taylor dispersion 
GenomicsThe ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation
CAMPARI2 CRISPR screening for SOCE modulators of ER stress. PC cells were sorted and sequenced for CRISPR whole KO library (De brie). Unsorted, SOrte din LOW PC and LOW PC Tunica treated fro 4hours were analysed.
ORGANISM(S): Mus musculus 
2023-12-09 | E-MTAB-13548 | biostudies-arrayexpress
Proteomics[HPP-2.0] Matrix Thermal Shift Assay for Fast Construction of Multidimensional Ligand–Target Space
Existing thermal shift-based mass spectrometry approaches are able to identify target proteins without chemical modification of the ligand, but they are suffering from complicated workflows with limited throughput. Herein, we present a new thermal shift-based method, termed matrix thermal shift assa...
ORGANISM(S): Homo Sapiens 
PXD045941 |
TranscriptomicsLigand and Target Discovery by Fragment-Based Screening in Human Cells
Advances in the synthesis and screening of small-molecule libraries have accelerated the discovery of chemical probes for studying biological processes. Still, only a small fraction of the human proteome has chemical ligands, and the full complement of proteins with potential to be targeted by small...
ORGANISM(S): Mus musculus 
2017-01-24 | GSE90731 | GEO
ProteomicsNative flow-induced dispersion analysis – mass spectrometry enables automated, multiplexed ligand screening from conventional, non-volatile buffers
Native electrospray ionisation mass spectrometry has become an important method for the validation, and the discovery of noncovalent ligands for therapeutic targets. As a label-free method combining high sensitivity and chemical specificity, it is ideally suited for this application. However, the pe...
ORGANISM(S): Homo sapiens (Human) 
2025-07-10 | PXD062598 | Pride
Fida Drug discovery Native mass spectrometry Lc-ms Ion mobility 
TranscriptomicsBiomarkers for Down Syndrome screening in murine fetal liver and placenta
The Ts1Cje mouse strain (Sago, 1998) contains a segmental trisomy of mouse chromosome 16 orthologous to the region of human chromosome 21 commonly associated with Down Syndrome. In this study, fetuses were obtained from wildtype mothers bred with either wildtype or Ts1Cje males. Gene expression prof...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-24272 | biostudies-arrayexpress
UnknownAccelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor.
Not available
S-EPMC6669887 | biostudies-literature
TranscriptomicsTranscription profiling of mouse wild-type and PPARI?-null liver treated with the synthetic PPARI? ligand WY14643
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8291 | biostudies-arrayexpress
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