Ligandability - OmicsDI

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DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed DrugMap, an atlas o...

ORGANISM(S): Homo sapiens (Human)

2024-04-23 | PXD047840 | Pride

Global profiling of arginine reactivity and ligandability

Despite the crucial biological roles of arginine, its reactivity and ligandability in the human proteome are not well-explored. In this study, we employed the activity-based protein profiling approach using phenylglyoxal-based chemical probes to globally profile arginine residues. By screening a foc...

ORGANISM(S): Homo Sapiens

PXD056202 |

Increased slow dynamics defines ligandability of BTB domains.

Not available

S-EPMC9668832 | biostudies-literature

DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.

Not available

S-EPMC11143475 | biostudies-literature

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.

Not available

S-EPMC11770632 | biostudies-literature

A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAP

Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile approach for small-molecule ligand discovery in native biological contexts. The covalent ligandability maps generated by ABPP that target cysteine have frequently leveraged the acrylamide as a reactive group d...

ORGANISM(S): Homo sapiens (Human)

2026-05-20 | PXD074619 | Pride

DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

PRJNA1079738 | ENA

Ligandability Assessment of Human Glutathione Transferase M1-1 Using Pesticides as Chemical Probes.

Not available

S-EPMC8998827 | biostudies-literature

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets.

Not available

S-EPMC11589570 | biostudies-literature

Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes.

Not available