Sort   by:  
 Page size 
UnknownCandidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases.

Aim

To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer (CRC) predisposing genes in early-onset or familial CRC cases.

Methods

We performed whole-exome sequencing in 23 Chinese patients from 21 families with non-p...
S-EPMC4394074 | biostudies-literature
TranscriptomicsThe MLH1 c.-27C>A and c.85G>T variants are borne on a European ancestral haplotype which underlies an autosomal dominant form of MLH1 epimutation.
Lynch syndrome, caused by germline heterozygous mutations of the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2, or deletions affecting the EPCAM gene upstream of MSH2, is characterized by a predisposition to early-onset colorectal and additional extracolonic cancers. An alternative but rare ca...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-45149 | biostudies-arrayexpress
Sort   by:  
 Page size