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ModelsLim2014 - HTLV-I infection A dynamic struggle between viral persistence and host immunity
This is a four-dimensional, non-linear system of ordinary differential equations that describes the dynamic interactions among viral expression, infected target cell activation, and the HTLV-I-specific CTL response.
2024-09-02 | BIOMD0000000887 | BioModels
MetabolomicsSmall Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
2021-11-04 | MTBLS788 | MetaboLights
UnknownMicroRNA Expression-Based Model Indicates Event-Free Survival in Pediatric Acute Myeloid Leukemia.
Not available
S-EPMC5721230 | biostudies-literature
UnknownA psychometric appraisal of a revised preparedness for medication administration questionnaire in final-year undergraduate nursing students: a secondary analysis.
Not available
S-EPMC11773837 | biostudies-literature
ProteomicsBC-APPS1: Anti-progestin therapy targets hallmarks of breast cancer risk through epithelial-stromal remodelling
Breast cancer (BC) is the leading cause of women's cancer death worldwide. Here, in the BC – Anti Progestin Prevention Study 1 (BC-APPS1; NCT02408770), we assess whether progesterone receptor antagonism with ulipristal acetate (UA) for 12 weeks reduces surrogate markers of BC risk in 24 premenopausa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD067122 | Pride
Prevention Breast cancer Laser capture proteomics 
MetabolomicsGlycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations ...
2022-01-11 | MTBLS3887 | MetaboLights
TranscriptomicsTranscription profiling of human T-ALL cell cultures treated with Compound E, a gamma-secretase inhibitor or vehicle only (DMSO) for 24 h
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T-cell development and in the pathogenesis over 50% of human T-cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcrip...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5827 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of mouse embryonic stem cells during retinoic acid-induced differentiation
Changes in microRNA expression profile during retinoic acid-induced differentiation of mouse embryonic stem cells.
ORGANISM(S): Mus musculus 
2007-04-01 | E-MEXP-977 | biostudies-arrayexpress
GenomicsAmplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint
Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent effects at the level of both target mRNA stability and chromatin structure. Using C. elegans undergoing RNAi as an animal model, we have investigated the generality, scope, and longevity of chromatin-targeted dsRNA effe...
ORGANISM(S): Caenorhabditis elegans 
2012-01-06 | E-GEOD-32631 | biostudies-arrayexpress
TranscriptomicsA nuclear Argonaute promotes germline immortality and epigenetic inheritance across generations
dsRNA-mediated gene silencing (RNAi) can be inherited for multiple generations in C. elegans. To understand this process we conducted a genetic screen for animals defective for transmitting RNAi silencing signals to future generations. This screen identified the gene heritable RNAi defective (hrde)-...
ORGANISM(S): Caenorhabditis elegans 
2012-07-30 | E-GEOD-38041 | biostudies-arrayexpress
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