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GenomicsSTAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex
The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing an...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-50993 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF-7 cells with inducible LMO4 and DN-Clim expression
The nuclear LIM-only protein LMO4 is upregulated in breast cancer, especially estrogen receptor negative tumors, and its overexpression in mice leads to hyperplasia and tumor formation. Here, we show that deletion of LMO4 in the mammary glands of mice leads to impaired lobuloalveolar development due...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-7382 | biostudies-arrayexpress
TranscriptomicsLim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival
Lhx8 is a member of the LIM-homeobox transcription factor family and preferentially expressed in oocytes and germ cells within the mouse ovary. We discovered that Lhx8 knockout females lose oocytes within 7 days after birth. At the time of birth, histological examination shows that Lhx8 deficient (L...
ORGANISM(S): Mus musculus 
2008-06-25 | E-GEOD-11897 | biostudies-arrayexpress
TranscriptomicsOverexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts
Four and a half LIM domains protein 2 (FHL2) is a co-regulator of gene transcription relevant for many signalling pathways and physiological processes. In this work, the role of FHL2 in cell differentiation has been investigated during in vitro mineralization using a Sparus aurata pre-osteoblast cel...
ORGANISM(S): Sparus aurata 
2013-01-03 | E-GEOD-32501 | biostudies-arrayexpress
TranscriptomicsIdentification of LMX1B target genes in a tet-off inducible HeLa cell line and in the mouse kidney
LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies; however, in the absence of in vivo molecular characterization of their regulation, their identity as direct LMX1B targets remains hypothet...
ORGANISM(S): Homo sapiens 
2008-12-03 | E-GEOD-12008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic kidney in Lim1 conditional mutant mice
Microarray experiment on each time point and genotype was performed in technical duplicates (ie. a single RNA preparation of pooled kidneys of one genotype used for two separate target preparations). Data from a total of 8 independent arrays were used in this study, 2 arrays were used for RNA sample...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-4230 | biostudies-arrayexpress
TranscriptomicsscRNA-seq from Trex1 KO in tumor
Single-cell RNA-seq data for Trex1 WT and KO mice from the tumor. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16526 | biostudies-arrayexpress
TranscriptomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [GRO-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64515 | biostudies-arrayexpress
TranscriptomicsscRNA-seq from Trex1 KO in heart
Single-cell RNA-seq data for Trex1 WT and KO mice from the heart. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16525 | biostudies-arrayexpress
TranscriptomicsStructural polymorphism in the promoter of pfmrp2 confers tolerance to mefloquine and chloroquine in Plasmodium falciparum [CGH]
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programs around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline based drugs is becoming critical. ...
ORGANISM(S): Plasmodium falciparum 
2013-02-07 | E-GEOD-44128 | biostudies-arrayexpress
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