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ProteomicsViral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing
TENT4 enzymes generate “mixed tails” on mRNAs by adding adenosines with intermittent non-adenosine residues, which protect mRNAs from deadenylation. Here we discover the extensive mixed tailing in the transcripts of two distinct DNA viruses, hepatitis B virus (HBV) and human cytomegalovirus (HCMV), ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-27 | PXD018061 | Pride
Rna modification Viral rna Rna-protein interaction 
Genomicsena-DATASET-GILD-07-06-2019-00:26:08:971-10 - samples
Deep sequencing of viral samples (average ~9,000x coverage) from patients chronically infected with Hepatitis B (HBV). Whole HBV genome sequencing of 1467 patients (1102 in discovery and 365 in validation cohort) chronically infected with HBV at baseline. The patient population contained HBV genot...
EGAD00001005075 | EGA
GenomicsLarge-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients
Despite the high global prevalence of chronic hepatitis B (CHB) infection, datasets covering the whole hepatitis B viral genome from large patient cohorts are lacking, greatly limiting our understanding of the viral genetic factors involved in this deadly disease. We performed deep sequencing of vir...
EGAS00001003689 | EGA
GenomicsDAC for hepatitis B analysis
Data Access Committee EGAC00001001228
EGAC00001001228 | EGA
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