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GenomicsSTAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex
The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing an...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-50993 | biostudies-arrayexpress
TranscriptomicsIsl1-Lhx3 fusion specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs
Combinatorial transcription codes generate the myriad of cell types during development, and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM-complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in e...
ORGANISM(S): Mus musculus 
2012-02-03 | E-GEOD-35510 | biostudies-arrayexpress
UnknownThe PDZ domain of the LIM protein enigma binds to beta-tropomyosin.
Not available
S-EPMC25398 | biostudies-literature
TranscriptomicsOverexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts
Four and a half LIM domains protein 2 (FHL2) is a co-regulator of gene transcription relevant for many signalling pathways and physiological processes. In this work, the role of FHL2 in cell differentiation has been investigated during in vitro mineralization using a Sparus aurata pre-osteoblast cel...
ORGANISM(S): Sparus aurata 
2013-01-03 | E-GEOD-32501 | biostudies-arrayexpress
UnknownAutoregulation of the LIM kinases by their PDZ domain.
Not available
S-EPMC10730565 | biostudies-literature
UnknownThe Roles of the LIM Domain Proteins in Drosophila Cardiac and Hematopoietic Morphogenesis.
Not available
S-EPMC7928361 | biostudies-literature
UnknownREST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor.
Not available
S-EPMC309669 | biostudies-literature
UnknownComprehensive Analyses and Immunophenotyping of LIM Domain Family Genes in Patients with Non-Small-Cell Lung Cancer.
Not available
S-EPMC10003053 | biostudies-literature
UnknownLIM Domain Proteins link molecular and global tension by recognizing strained actin in adhesions.
Not available
S-EPMC12338669 | biostudies-literature
UnknownTandem LIM domain-containing proteins, LIMK1 and LMO1, directly bind to force-bearing keratin intermediate filaments.
Not available
S-EPMC11610427 | biostudies-literature
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