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UnknownStructural Aspects of LIMK Regulation and Pharmacology.
Not available
S-EPMC8750758 | biostudies-literature
UnknownTetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors.
Not available
S-EPMC12406257 | biostudies-literature
UnknownLIMK (LIM Kinase) Inhibition Prevents Vasoconstriction- and Hypertension-Induced Arterial Stiffening and Remodeling.
Not available
S-EPMC7347448 | biostudies-literature
TranscriptomicsMYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis
Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26721 | biostudies-arrayexpress
UnknownFMNL2 suppresses cell migration and invasion of breast cancer: a reduction of cytoplasmic p27 via RhoA/LIMK/Cofilin pathway.
Not available
S-EPMC8980084 | biostudies-literature
UnknownWIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells.
Not available
S-EPMC5437570 | biostudies-literature
UnknownThe Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse.
Not available
S-EPMC8076898 | biostudies-literature
UnknownDiscovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.
Not available
S-EPMC11726654 | biostudies-literature
TranscriptomicsTranscription profiling of human A549 lung cancer cells treated with compounds from a series of inhibitors developed against the human LIM kinases LIMK1 and LIMK2
To investigate an unknown mechanism of cytotoxicity, A549 human lung-cancer cells were treated with compounds from a series of inhibitors developed against the human LIM kinases LIMK1 and LIMK2. Compounds 1 and 2 inhibit LIM kinase activity in vitro and affect cell proliferation and survival in vivo...
ORGANISM(S): Homo sapiens 
2008-09-17 | E-TABM-450 | biostudies-arrayexpress
UnknownThe Activation of the LIMK/Cofilin Signaling Pathway via Extracellular Matrix-Integrin Interactions Is Critical for the Generation of Mature and Vascularized Cardiac Organoids.
Not available
S-EPMC10453200 | biostudies-literature
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