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TranscriptomicsChronic myelogenous leukemia hematopoietic stem cells
We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin- CD34-) hematopoietic stem cells (HSCs) from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular caryotyping and quantitative analysis of BCR/ABL transcript demonstrated...
ORGANISM(S): Homo sapiens 
2010-01-04 | E-GEOD-11675 | biostudies-arrayexpress
UnknownThe C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.
Not available
S-EPMC3445323 | biostudies-literature
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
TranscriptomicsTranscription profiling of various types of murine cerebellum cells to investigate the pre-neoplastic stage of medulloblastoma
SUMMARY; Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here we identify a pre-neoplastic stage of medulloblas...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2426 | biostudies-arrayexpress
TranscriptomicsElevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: Implications for prostate cancer progression
Background: Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cance...
ORGANISM(S): Homo sapiens 
2010-08-10 | E-GEOD-20956 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of CD14+ CD163high CD160high cells in human intestinal lamina propria
Several innate immune cell subsets have recently been identified to maintain gut homeostasis in both human and mice. Among these subsets, CX3CR1high CD11b+ CD11c+ cells contribute to intestinal tolerance through various mechanisms in mice. However, whether tolerogenic innate myeloid cells are presen...
ORGANISM(S): Homo sapiens 
2016-07-17 | E-GEOD-79627 | biostudies-arrayexpress
UnknownN-cadherin antagonism is bronchoprotective in severe asthma models.
Not available
S-EPMC11606448 | biostudies-literature
UnknownSafety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced, PD-L1-positive papillary or follicular thyroid cancer.
Not available
S-EPMC6399859 | biostudies-literature
UnknownAtherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation.
Not available
S-EPMC8795425 | biostudies-literature
UnknownTocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study.
Not available
S-EPMC7428303 | biostudies-literature
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