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TranscriptomicsExpression profiling, Lin-9 depletion array in D3 mES cells
Lin-9 was depleted in ES-D3 cells (ATCC CRL-1934) and the resulting expression profile changes mapped via microarrays
ORGANISM(S): Mus musculus 
2013-05-13 | E-MTAB-1490 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of LSK (lineage negative, Sca-1+, c-Kit+) cells isolated by fluorescence-activated cell sorting from the bone marrow of control young C57Bl/6Jax mice
Hematopoietic stem cells (HSCs) and different multipotent progenitor populations (MPPs) contained in the Lin- Sca-1+ c-Kit+ (LSK) compartment have previously been identified using diverse surface marker panels. However, a comprehensive and complete characterization of the complete LSK compartment is...
ORGANISM(S): Mus musculus 
2021-05-13 | E-MTAB-9208 | biostudies-arrayexpress
TranscriptomicsExpression data from human hematopoietic stem and progenitor compartments from patients with acute myeloid leukemia with normal karyotype and healthy controls
We applied a novel approach of parallel transcriptional analysis of multiple, highly fractionated stem and progenitor populations from patients with acute myeloid leukemia (AML) and a normal karyotype. We isolated phenotypic long-term HSC (LT-HSC), short-term HSC (ST-HSC), and committed granulocyte-...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-35008 | biostudies-arrayexpress
TranscriptomicsExpression data from human hematopoietic stem and progenitor compartments from patients with acute myeloid leukemia with monosomy 7 and healthy controls
We applied a novel approach of parallel transcriptional analysis of multiple, highly fractionated stem and progenitor populations in a genetically defined subset of AML (AML with monosomy 7). We isolated phenotypic long-term HSC (LT-HSC), short-term HSC (ST-HSC), and committed granulocyte-monocyte p...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-35010 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embyronic fibroblasts from wild type and Lin9 knockout strains treated with 4-hydroxytestosterone
We used microarrays to analyze the role of Lin9 in gene expression. Experimental overall design: We prepared MEFs from embyos containing a conditional allele of Lin9 and a CreERT2 transgene. Transcriptional profiles of untreated and 4-OHT-treated MEFs were compared.
ORGANISM(S): Mus musculus 
2010-03-31 | E-MEXP-2097 | biostudies-arrayexpress
TranscriptomicsATAC-seq of LT-HSCs and MPPs
The open chromatin of mouse longterm hematopoietic stem cells and multipotent progenitor cells has been profiled by ATAC-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9779 | biostudies-arrayexpress
TranscriptomicsDNA microarrays of ovaries tissues from postmenopausal women against premenopausal women
The aim of the experiment was to identify the change of gene expression in human ovaries between premenopausal women and postmenopausal women based on DNA microarrays analysis. 8 human ovary samples were assembled from premenopausal women (n=4) and from postmenopausal women (n=4), respectively. The ...
ORGANISM(S): Homo sapiens 
2022-08-19 | E-MTAB-11494 | biostudies-arrayexpress
GenomicsChIPseq for H3K4me3 and H3K27me3 in LT-HSCs and MPPs
The distribution of H3K4- and H3K27me3 on the chromatin of mouse longterm hematopoietic stem cells and multipotent progenitor cells has been profiled by ChIP-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-10661 | biostudies-arrayexpress
TranscriptomicsATAC-seq of control and Cyp26b1KO HSCs
The open chromatin of mouse control and Cyp26b1KO longterm hematopoietic stem cells has been profiled by ATAC-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9778 | biostudies-arrayexpress
TranscriptomicsATAC-seq of HSCs in Vitamin A-free diet
The open chromatin of mouse longterm hematopoietic stem cells in control and vitamin A deficiency has been profiled by ATAC-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9780 | biostudies-arrayexpress
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