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UnknownPreclinical evidence for the effective use of TL-895, a highly selective and potent second-generation BTK inhibitor, for the treatment of B-cell malignancies.
Not available
S-EPMC10663516 | biostudies-literature
TranscriptomicsTranscription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress
TranscriptomicsNotch/HES1-mediated PARP1 activation: A cell-type specific mechanism for tumor suppression
Notch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T cell acute lymphoblastic leukemia (T-ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-ALL leads to growth arrest and apoptosis. The Notch target Hairy/Enha...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-26366 | biostudies-arrayexpress
UnknownIncidence and Outcomes of Patients With Oral Cavity Squamous Cell Carcinoma and Fourth Primary Tumors: A Long-term Follow-up Study in a Betel Quid Chewing Endemic Area.
Not available
S-EPMC4998365 | biostudies-literature
TranscriptomicsGene expression analysis of leukemic samples in C57BL6 mice
[original title] Gene expression analysis of leukemic samples derived from AF4-MLL- or AF4-MLL/MLL-AF4-transduced and transplanted hematopoietic stem/precursor cells in C57BL6 mice. We used microarrays to analyze the global gene expression in leukemic cells with three distinct immunophenotypes. We ...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-20519 | biostudies-arrayexpress
UnknownTopical fluorometholone treatment for ocular dryness in patients with Sjogren syndrome: a randomized clinical trial in China.
Not available
S-EPMC4554178 | biostudies-literature
ProteomicsThe sulfonic-containing peptides (at C281) from trypsin-treated Orf1 in H218O.
Oxidized cysteine residues are highly reactive and can form functional covalent conjugates, of which the allosteric redox switch formed by the lysine-cysteine NOS bridge is an example. Here, we report a non-canonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycin...
ORGANISM(S): Escherichia coli 
2023-05-10 | PXD041103 | Pride
N-formimmidolation and iminoacetylation enzyme 
ProteomicsMass spectrometric analyses for the C281-dimedone adduct and the sulfinylated peptide fragments of Orf1
Oxidized cysteine residues are highly reactive and can form functional covalent conjugates, of which the allosteric redox switch formed by the lysine-cysteine NOS bridge is an example. Here, we report a non-canonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycin...
ORGANISM(S): Escherichia coli 
2023-05-10 | PXD041104 | Pride
N-formimmidolation and iminoacetylation enzyme 
TranscriptomicsExpression profiling of primary leukemia initiating cell-enriched population induced by AML1-ETO9a
Combined gene expression and DNA occupancy profiling identifies JAK/STAT signaling as a valid therapeutic target of t(8;21) AML t(8;21) is commonly associated with acute myeloid leukemia (AML). The resulting AML1-ETO fusion proteins are involved in the pathogenesis of AML. To identify novel molecul...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-15195 | biostudies-arrayexpress
ProteomicsMass spectrometric analyses of the oxidation state of Cys281 in peptide fragment.
Oxidized cysteine residues are highly reactive and can form functional covalent conjugates, of which the allosteric redox switch formed by the lysine-cysteine NOS bridge is an example. Here, we report a non-canonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycin...
ORGANISM(S): Escherichia coli 
2023-05-10 | PXD041105 | Pride
N-formimmidolation and iminoacetylation enzyme 
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