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ProteomicsChimeric design of Pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion
An orthogonal aminoacyl-tRNA synthetase/tRNA pair is a key prerequisite for site-specific incorporation of unnatural amino acids. Due to its high codon suppression efficiency and full orthogonality, the pyrrolysyl-tRNA synthetase/pyrrolysyl-tRNA pair is currently the ideal system for genetic code ex...
ORGANISM(S): Escherichia coli 
2020-05-25 | PXD018660 | Pride
Chimeric design Genetic code expansion 
ProteomicsRecoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids
Expanding the genetic code has revolutionized our ability to study and manipulate biological systems through site-specific incorporation of noncanonical amino acids (ncAAs). However, current methods are primarily limited to single-type ncAA incorporation in mammalian cells owing to translation ineff...
ORGANISM(S): Homo Sapiens 
2025-11-04 | PXD070277 |
ProteomicsMS analysis of human TFEB posttranslational modification
Mass spectrometry analysis of TFEB acetylation, phosphorylation, and ubiquitination without or with TSA treatment
ORGANISM(S): Homo Sapiens 
2022-08-08 | PXD035879 |
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