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TranscriptomicsPAX3-FOXO1 suppresses cellular senescence through RASSF4-mediated restraint of the mammalian Hippo/MST1 pathway
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the PAX3-FOXO1 fusion gene. Despite its discovery over almost 20 years ago, PAX3-FOXO1 remains an enigmatic tumor driver. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by en...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-40543 | biostudies-arrayexpress
TranscriptomicsSecreted frizzled related protein 3 (SFRP3) is required for tumorigenesis of PAX3-FOXO1-positive alveolar rhabdomyosarcoma
Alveolar rhabdomyosarcoma (aRMS) is a soft tissue sarcoma associated with the skeletal muscle lineage. The majority of aRMS tumors express the fusion protein PAX3-FOXO1 (PF), which has proven chemically intractable. As such, we identified proteins downstream from or cooperate with PF to support tu...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-67999 | biostudies-arrayexpress
UnknownExpression of oncogenic HRAS in human Rh28 and RMS-YM rhabdomyosarcoma cells leads to oncogene-induced senescence.
Not available
S-EPMC8363632 | biostudies-literature
TranscriptomicsExpression profile of zebrafish embryonal rhabdomyosarcoma
Fluorescent-labeled zebrafish RAS-induced embryonal rhabdomyosarcoma (ERMS) were created to facilitate in vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in diverse cellular compartments. Using this strategy, we have identified a molecularly distinc...
ORGANISM(S): Danio rerio 
2012-12-01 | E-GEOD-32425 | biostudies-arrayexpress
UnknownDistinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.
Not available
S-EPMC3893104 | biostudies-literature
UnknownCDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-driven Alveolar Rhabdomyosarcoma.
Not available
S-EPMC12338617 | biostudies-literature
UnknownPredicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group.
Not available
S-EPMC9843436 | biostudies-literature
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