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MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
MetabolomicsMolecular structural diversity of mitochondrial cardiolipins
Current strategies used to quantitatively describe the biological diversity of lipids by mass spectrometry are often limited in assessing the exact structural variability of individual molecular species in detail. A major challenge is represented by the extensive isobaric overlap present among lipid...
2021-01-11 | MTBLS636 | MetaboLights
ProteomicsPredictive protein biomarker signatures and the corresponding transcriptional cell state changes in human lung fibrosis (Plasma)
Single cell genomics enables characterization of disease specific cell states, while improvements in mass spectrometry workflows bring the clinical use of body fluid proteomics within reach. However, the correspondence of peripheral protein signatures to changes in cell state in diseased organs is c...
ORGANISM(S): Homo sapiens (Human) 
2020-09-18 | PXD017210 | Pride
Data integration Proteomics Fibrosis Single cell rna-seq Systems medicine Biomarker 
ProteomicsPredictive protein biomarker signatures and the corresponding transcriptional cell state changes in human lung fibrosis
Single cell genomics enables characterization of disease specific cell states, while improvements in mass spectrometry workflows bring the clinical use of body fluid proteomics within sight. However, the correspondence of peripheral protein signatures with cell state changes in diseased organs is cu...
ORGANISM(S): Homo sapiens (Human) 
2020-09-18 | PXD017145 | Pride
Data integration Proteomics Fibrosis Single cell rna-seq Systems medicine Biomarker 
UnknownIntegrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers
Not available
S-SCDT-EMM-2020-12871 | biostudies-other
UnknownLAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
Not available
S-JCBD-201703061 | bioimages
UnknownThe effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.
Not available
S-EPMC3145073 | biostudies-literature
UnknownDissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.
Not available
S-EPMC8851871 | biostudies-literature
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