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MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
UnknownActive idiotypic vaccination versus control immunotherapy for follicular lymphoma.
Not available
S-EPMC4039868 | biostudies-literature
GenomicsCiliopathies Exome Sequencing Initiative

The study is aimed at identifying new genes involved in pediatric brain disorders from inbred families originating predominantly in the Middle East. Each patient analyzed to date has a specific and highly unique neurodevelopmental disorder that is likely to be recessive in nature. Many patien...

phs000288.v1.p1 | EGA
TranscriptomicsSuppression of Lung Adenocarcinoma Progression by Nkx2-1
Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-p...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26874 | biostudies-arrayexpress
TranscriptomicsIGR_MACROPHAGE_MOUSE_MUTATION_CEA_PHR
Macrophage activation during the innate immune response is tightly regulated to prevent tissue damage while activating the defense to cellular attack. Using a mouse model where Trim33 is specifically deleted in mature myeloid cells, we show that TRIM33 is essential for two aspects of the inflammator...
ORGANISM(S): Mus musculus 
2015-06-30 | E-MTAB-1441 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profiling or ERCC1 deficient and control mouse lineage negative bone marrow cells
MiRNA expression differences induced by ERCC1 deficiency.
ORGANISM(S): Mus musculus 
2015-04-09 | E-MTAB-3298 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profiling or ERCC1 deficient and control mouse lineage negative, ScaI positive, Kit positive (LSK) bone marrow cells
MiRNA expression differences induced by ERCC1 deficiency.
ORGANISM(S): Mus musculus 
2015-04-09 | E-MTAB-3310 | biostudies-arrayexpress
TranscriptomicsGene expression profiling or ERCC1 deficient and control mouse lineage negative bone marrow cells
Transcriptome differences induced by ERCC1 deficiency.
ORGANISM(S): Mus musculus 
2015-04-09 | E-MTAB-3297 | biostudies-arrayexpress
TranscriptomicsLoss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC indu...
ORGANISM(S): Mus musculus 
2015-08-07 | E-GEOD-68808 | biostudies-arrayexpress
TranscriptomicsReduced atherosclerosis in MyD88 null mice
This series represents a comparison of gene expression in mouse aorta from MyD88-/-, apoE-/- mice versus apoE-/- control mice fed a high fat diet for 8 weeks, causing atherosclerotic lesion development. 5 MyD88-/-, apoE-/- mice were compared to 5 apoE-/- control mice and dye swap replicated for a to...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-1058 | biostudies-arrayexpress
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