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MetabolomicsConjugated linoleic acid (CLA) study in LDLR-/- mice
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ORGANISM(S): Mus musculus 
ST000299 | MetabolomicsWorkbench
MetabolomicsMycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages

Regulatory T cells (Tregs) expand during Mycobacterium tuberculosis (Mtb) infection and suppress T cell mediated control. Whether Mtb actively contributes to this process is unclear. Here, using a genome-wide mutant library, we show that expression of Mtb Rv1272c, an ATP-binding cassette transpor...

2025-09-28 | MTBLS12875 | MetaboLights
MetabolomicsFisetin ameliorates acute colitis in mice via gut microbiota associated linoleic acid metabolism to regulate Th17/Treg balance

This study investigated the therapeutic effects of FST on colitis in mice by exploring its impact on the gut microbiota, metabolites, and immune response. The results show FST alleviated colitis in mice, including mitigated weight loss, improved colon length shortening, and reduced mRNA expressi...

2025-12-03 | MTBLS13284 | MetaboLights
TranscriptomicsTranscription profiling of human Caco-2 cells treated with conjugated linoleic acid (CLA)
The effect of CLA on gene expression in Caco-2 cells Experiment Overall Design: Caco-2 cells were treated with linoleic acid (LA; the parent and control fatty acid) trans-10, cis-12 CLA or cis-9, trans-11 CLA for 12 d.
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6518 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of mice OTI cells treated with Linoleic acid against an untreated control
Using RNA-seq to map the differentially expressed genes in OTI cells of mice activated for 48 hours in the presence of Linoleic acid and as a control in absence of Linoleic acid.
ORGANISM(S): Mus musculus 
2023-06-01 | E-MTAB-12645 | biostudies-arrayexpress
TranscriptomicsEicosapentaenoic acid improves metabolic switching in human myotubes
Metabolically healthy skeletal muscle is characterized by the ability to switch easily between glucose and fat oxidation, whereas loss of this ability seems to be related to insulin resistance. The aim of this study was to investigate whether different fatty acids (FAs) and the LXR ligand T0901317 a...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18589 | biostudies-arrayexpress
TranscriptomicsNon-alcoholic steatohepatitis causes selective CD4+ T cell loss and promotes hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer related death. NAFLD affects a large proportion of the US population. Its incidence and prevalence are increasing to epidemic proportions around the world and is known to increase the risk of HCC. We studied how intrahepatic li...
ORGANISM(S): Mus musculus 
2016-03-10 | E-GEOD-67918 | biostudies-arrayexpress
TranscriptomicsConjugated linoleic acid activates AMPK and reduces adiposity more effectively when used with metformin
Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) causes dramatic reductions in white adipose tissue in mice but has had limited effectiveness in humans. Determination of the signaling pathways involved may lead to better regulation of adiposity. T10c12 CLA was found to activate AMP-activating...
ORGANISM(S): Mus musculus 
2009-11-01 | E-GEOD-14888 | biostudies-arrayexpress
MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
TranscriptomicsTranscription profiling of mouse adipocytes treated with trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes (GEO Super Series)
This SuperSeries is composed of the following subset Series:; GSE8679: Gene expression in mouse white adipose tissue; GSE8681: Gene expression in mouse 3T3-L1 adipocyte tissue culture treated with CLA; GSE8682: Gene expression in mouse 3T3-L1 adipocyte tissue culture treated with tunicamycin; GSE868...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-11384 | biostudies-arrayexpress
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