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MetabolomicsSacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
Dietary ω-3 polyunsaturated fatty acids (PUFAs) are beneficial for humans against the development of hyperlipidaemia, but the underlying mechanisms are still poorly understood. Here, we demonstrated that oral consumption of sacha inchi oil, which is rich in α-linolenic acid, alleviated dyslipidemia,...
2022-02-21 | MTBLS1225 | MetaboLights
MetabolomicsPersistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease

OBJECTIVES: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply ...

2020-01-22 | MTBLS729 | MetaboLights
MetabolomicsWlingsan ameliorates high-fat diet-induced lipid metabolism disorder

In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molec...

2026-08-26 | MTBLS14691 | MetaboLights
MetabolomicsHuanglianjiedu Decoction ameliorates high-fat diet-induced lipid metabolism disorder
In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molecula...
2026-08-26 | MTBLS14701 | MetaboLights
MetabolomicsYinchenhao Decoction ameliorates high-fat diet-induced lipid metabolism disorder

In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molec...

2027-06-26 | MTBLS14689 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
MetabolomicsDendrobium officinale Polysaccharide Ameliorates High-Fat Diet-Induced Hepatic Lipid Metabolic Disorder via the SIRT6/PGC-1α Signaling Axis
Aims: This study aims to explore the potential therapeutic effect of Dendrobium officinale polysaccharide (DOP) on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD), and to elucidate the underlying mechanism involving the SIRT6/PGC-1α signaling axis and the regulation of the g...
2026-05-25 | MTBLS14575 | MetaboLights
MetabolomicsLipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...
2014-08-19 | MTBLS26 | MetaboLights
MetabolomicsDietary Cetobacterium somerae LY-01 improves lipid metabolism and intestinal health in largemouth bass (Micropterus salmoides) fed a high-fat diet
Non-targeted metabolomics sequencing was performed on the control group diet (C), the high-fat group diet (H), and the high-fat + Cetobacterium somerae LY-01 (HCS9) diet to investigate their effects on intestinal health.
2026-09-03 | MTBLS15536 | MetaboLights
MetabolomicsMulti-omics Elucidates Gut Microbiota-Driven Mechanisms of Lipid Deposition in Pigs Fed a DDGS Diet

Abstract:

Background: Corn dried distillers’ grains with solubles (DDGS) is a cost-effective alternative feed ingredient in swine diets. However, its negative impact on carcass fat quality, characterized by increased polyunsaturated fatty acids (PUFAs) and reduced fat firmness, fundamentall...

2026-03-16 | MTBLS14058 | MetaboLights
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