Sort   by:  
 Page size 
ProteomicsLipid-specific metabolic labelling reveals site-specific heterogeneity in long-chain S-acylation
Long-chain S-acylation is a post-translational modification that regulates key cellular processes, including signal transduction and metabolic regulation. However, the dynamic nature, and site- and lipid-specific patterns of long-chain protein acylation remain poorly understood. Site- and lipid-spec...
ORGANISM(S): Homo sapiens (Human) 
2026-06-30 | PXD066568 | Pride
Liquid chromatography Tandem mass spectrom-etry Lipid metabolic labelling Long-chain s-acylation 
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
MetabolomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to st...

2025-04-25 | MTBLS12329 | MetaboLights
TranscriptomicsS1P lyase deficiency disrupts lipid homeostasis in liver
The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway. We have studied mice with an inactive S1P lyase gene and have found that, in addition to the expec...
ORGANISM(S): Mus musculus 
2010-02-05 | E-GEOD-18745 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver and mammary gland from lactating or pregnant animals fed on low or high energy diets to test the hypothesis that multiple metabolic control points and potential regulatory mechanisms are involved in activating lipid and lactose synthesis at the onset of lactation
The mammary gland of the lactating mouse synthesizes and secretes milk lipid equivalent to its entire body weight in a single 20 day lactation cycle, making it one of the most active lipid synthetic organs known. To test the hypothesis that multiple metabolic control points and potential regulatory ...
ORGANISM(S): Mus musculus 
2007-12-12 | E-GEOD-4222 | biostudies-arrayexpress
TranscriptomicsCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-b...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-32357 | biostudies-arrayexpress
TranscriptomicsEffects of bisphenol A on gene expression in adipocytes from lean children: association to metabolic disorders
Bisphenol A (BPA) is a xenobiotic endocrine disrupting chemical. In vitro and in vivo studies indicated that BPA alters endocrine-metabolic pathways in adipose tissue increasing the risk of developing metabolic disorders. BPA effects on human adipocytes, specifically in children, are poorly investig...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-58516 | biostudies-arrayexpress
MetabolomicsThe diversity of quinoa morphological traits and seed metabolic composition

Quinoa (Chenopodium quinoa Willd.) is an herbaceous annual crop of the amaranth family (Amaranthaceae). It is increasingly cultivated for its nutritious grains, which are rich in protein and essential amino acids, lipids, and minerals. Quinoa exhibits a high tolerance towards various abi...

2022-03-10 | MTBLS2382 | MetaboLights
TranscriptomicsTranscription profiling of liver from PPARalpha knockout mice: PPARa -dependent regulation of hepatic lipid metabolism by expression profiling (GEO Super series)
This SuperSeries is composed of the following subset Series:; GSE8290: Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 1; GSE8291: Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 2...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8316 | biostudies-arrayexpress
TranscriptomicsRaptor/mTORC1-dependent metabolic programming of exit from quiescence underlies T cell activation and fate decisions
Naïve T cells respond to antigen stimulation by exiting from quiescence into clonal expansion and functional differentiation, but the control mechanism is elusive. Here we describe that Raptor/mTORC1-dependent metabolic reprogramming is a central determinant of this transitional process. Loss of Rap...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51668 | biostudies-arrayexpress
Sort   by:  
 Page size