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The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-b...
ORGANISM(S): Homo sapiens 
Purpose: The goals of this study are to investigate the mRNAs that bind to the FTO protein in the white fat tissue from mice. Methods: 1. White fat from CAG promoter driven transgenic Flag-tagged FTO mice were extracted with RNA protected. 2. Flag-FTO proteins were immunoprecipitated with control I...
ORGANISM(S): Mus musculus 
Lipolysis regulates major transcriptional programs in brown adipocytes
Lipolysis regulates major transcriptional programs in brown adipocytes [hBA]
Lipolysis regulates major transcriptional programs in brown adipocytes [DOX exp]
Lipolysis regulates major transcriptional programs in brown adipocytes [3Dcultured_eWAs_RNA-seq]
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