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TranscriptomicsTranscription profiling of mouse T cell populations undergoing negative or positive selection for an Aire-dependent organ specific antigen
Background. T cells in the thymus undergo opposing positive and negative selection processes so that the only T cells entering circulation are those bearing a T cell receptor (TCR) with a low affinity for self. The mechanism differentiating negative from positive selection is poorly understood, desp...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3997 | biostudies-arrayexpress
TranscriptomicsComparative assessment of the transcriptome of pancreatic islets from Non-Obese Diabetic mice in the absence of immune infiltrate
The transcriptome of pancreatic islets from four mouse strains was compared - NODk.RagKO, B10k.RagKO, NODk.RagKO.insHEL and B10k.RagKO.insHEL. This comparison allows the assessment of altered transcriptome due to two factors - genetic background of NOD vs B10 strain, and the effect of the insHEL tra...
ORGANISM(S): Mus musculus 
2016-02-23 | E-GEOD-56507 | biostudies-arrayexpress
TranscriptomicsAire regulates transfer of antigen from mTEC to dendritic cells for induction of thymic tolerance
To investigate the role of Aire in thymic selection, we examined the cellular requirements for generation of ovalbumin (OVA)-specific CD4 and CD8 T cells in mice expressing OVA under the control of the rat insulin promoter (RIP). Aire-deficiency reduced the number of mature single positive (SP) O...
ORGANISM(S): Mus musculus 
2011-04-06 | E-GEOD-28393 | biostudies-arrayexpress
TranscriptomicsQuorum sensing in CD4+ T cells homeostasis : IL-2 coordinates the interplay between IL-2p and regulatory T cells.
Many species of bacteria use quorum sensing to sense the amounts of secreted metabolites and adapt their growth according to their population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. We investigated the regulation of the size of Interleukin-2-producing CD...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-50149 | biostudies-arrayexpress
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