Sort   by:  
 Page size 
TranscriptomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression)
We have used an unbiased systems approach to predict that a member of the forkhead family of transcription factors, FOXO3, is a negative regulator of a subset of antiviral genes. This prediction was validated using macrophages isolated from Foxo3-null mice. We detected significantly increased transc...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-37051 | biostudies-arrayexpress
GenomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq)
We predict that a member of the forkhead family of transcription factors, FOXO3, is a negative regulator of a subset of antiviral genes. This prediction was validated using macrophages isolated from Foxo3-null mice. Genome-wide location analysis combined with gene deletion studies identified the Irf...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-36241 | biostudies-arrayexpress
TranscriptomicsTranscriptional study of oxLDL-induced foam cell formation in WT and Atf3-/- murine bone marrow macrophages
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-loaded macrophages in the arterial wall. Intimal macrophages internalize modified lipoproteins such as oxidized LDL (oxLDL) through scavenger receptors, leading to storage of excess cholesteryl esters in lip...
ORGANISM(S): Mus musculus 
2012-03-23 | E-GEOD-32358 | biostudies-arrayexpress
Sort   by:  
 Page size