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TranscriptomicsRNA sequencing analysis of DAF-16 target gene expression when math-33 function is genetically inactivated
In this study we have investigated the effect of loss of math-33 activity on DAF-16-mediated target gene regulation in C. elegans under conditions of reduced Insulin/IGF-1 signaling (IIS). Using whole nematode RNA sequencing experiments we found that the daf-2(e1370)-mediated induction and repressio...
ORGANISM(S): Caenorhabditis elegans 
2016-06-22 | E-GEOD-70117 | biostudies-arrayexpress
UnknownAdjuvant Lapatinib and Trastuzumab for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Results From the Randomized Phase III Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Trial.
Not available
S-EPMC4872016 | biostudies-literature
TranscriptomicsThe translational landscape of mTOR signaling steers cancer initiation and metastasis
The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream translationally regulated nodes of gene expression that may direct cancer development are poorly characterized. Employing riboso...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35469 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation study of hip and knee osteoarthritic and healthy cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis
Cartilage samples were collected from hip or knee joint replacement patients either due to primary OA or hip fractures as controls. DNA was extracted from the collected cartilage and assayed by Illumina Infinium HumanMethylation450 ‎BeadChip array, which allows for the analysis of >480,000 CpG sit...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-73626 | biostudies-arrayexpress
GenomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [ChIP-seq]
Children with Down syndrome (DS) have a 20-fold increased risk of developing B cell acute lymphoblastic leukemia (B-ALL). Polysomy 21 (i.e., extra copies of chr.21) is also the most frequent somatic aneuploidy among all B-ALLs. Additional B-ALLs harbor intrachromosomal amplifications of chr.21q22 (i...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48534 | biostudies-arrayexpress
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Changes and Childhood Asthma in the Inner City [gene expression]
Background: Epigenetic marks, like asthma, are heritable. They are influenced by the environment, direct the maturation of T cellslymphocytes, and have been shown to enhance the development of allergic airways disease in mice. Thus, we hypothesized that epigenetic marks are associated with allergi...
ORGANISM(S): Homo sapiens 
2015-02-02 | E-GEOD-40732 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Changes and Childhood Asthma in the Inner City [methylation]
Background: Epigenetic marks, like asthma, are heritable. They are influenced by the environment, direct the maturation of T cellslymphocytes, and have been shown to enhance the development of allergic airways disease in mice. Thus, we hypothesized that epigenetic marks are associated with allergi...
ORGANISM(S): Homo sapiens 
2015-02-02 | E-GEOD-40576 | biostudies-arrayexpress
TranscriptomicsRobust enumeration of cell subsets from tissue expression profiles (BeadChip)
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen, and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with r...
ORGANISM(S): Homo sapiens 
2015-03-29 | E-GEOD-65133 | biostudies-arrayexpress
UnknownGenome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.
Not available
S-EPMC6248554 | biostudies-literature
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