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GenomicsH2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation
Chromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the function of histone variant H2A.Z in ESCs remains unclear. We show that H2A.Z is highly enriched at promoters and enhancers and is required for both efficient self-renewa...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-34483 | biostudies-arrayexpress
ProteomicsMICU3 Plays an Important Role in Cardiovascular Function
Mitochondrial calcium regulates bioenergetics but also serves as a trigger for cell death.1 With a sustained increase in catecholamine or a large increase in cytosolic calcium as occurs with ischemia, mitochondrial calcium can rise to high levels, leading to activation of the mitochondrial permeabil...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-11-23 | MSV000088439 | MassIVE
TranscriptomicsCritical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function (RNA)
Cytokine-activated STAT proteins dimerize and bind to high-affinity motifs, and N-terminal domain-mediated oligomerization of dimers allows tetramer formation and binding to low-affinity tandem motifs, but the functions of dimers versus tetramers are unknown. We generated Stat5a and Stat5b double kn...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-36888 | biostudies-arrayexpress
Genomicsena-DATASET-CAS_CN-25-05-2017-05:37:34:660-591 - samples
The differentiation of distinct multifocal hepatocellular carcinoma (HCC): multicentric disease vs. intrahepatic metastases, in which the management and prognosis varies substantively, remains problematic. We aim to stratify multifocal HCC and identify novel diagnostic and prognostic biomarkers by p...
EGAD00001003348 | EGA
GenomicsPoly(A) RNA sequencing of hepatocellular carcinoma tumors and their matched noncancerous liver tissues
Background & Aims: The differentiation of distinct multifocal hepatocellular carcinoma (HCC): multicentric disease vs. intrahepatic metastases, in which the management and prognosis varies substantively, remains problematic. We aim to stratify multifocal HCC and identify novel diagnostic and prognos...
EGAS00001002337 | EGA
Genomicswhole genome sequence data of multifocal hepatocellular carcinoma
Background & Aims: The differentiation of distinct multifocal hepatocellular carcinoma (HCC): multicentric disease vs. intrahepatic metastases, in which the management and prognosis varies substantively, remains problematic. We aim to stratify multifocal HCC and identify novel diagnostic and prognos...
EGAS00001002338 | EGA
Genomicsena-DATASET-CAS_CN-17-03-2017-16:16:33:917-247 - samples
Poly A transcriptome sequence of mutifocal hepatocelular carcinoma
EGAD00001003231 | EGA
GenomicsPUMCH-ICT Hepatocellular Carcinoma Study Data Access Committee
Data Access Committee EGAC00001000627
EGAC00001000627 | EGA
GenomicsPUMCH-ICT Hepatocellular Carcinoma Study Data Access Committee
Data Access Committee EGAC00001000070
EGAC00001000070 | EGA
GenomicsBreast Cancer Suppressor Role of RUNX1: Estrogen-dependent Regulation of AXIN1 and b-catenin
The transcription factor RUNX1 exhibits recurrent loss-of-function mutations in estrogen receptor-positive (ER+) breast cancer (BCa). Its knockdown in vitro decreased AXIN1 expression in estrogen-dependent manner. Consistently, RUNX1 and AXIN1 mRNA levels are strongly correlated in ER+, not ER- tu...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-65313 | biostudies-arrayexpress
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