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MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
MetabolomicsMetabolomics to elucidate the effects of novel sustainable feed additives in the feed of farmed salmon (HoloFood Trial D - fermented seaweed open water-dose response)

Testing the effect of seaweed as a novel cost-efficient feed source for Atlantic salmon feed. Fermentation of novel raw materials for fish feed is a new practice with little prior experience of direct relevance to aquaculture and fish farming. In Trial D, an alternative marine compound is include...

2023-06-13 | MTBLS6733 | MetaboLights
TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
TranscriptomicsmRNA and sRNA Transcriptomes Reveal Insights into Dynamic Homoeolog Regulation for Allopolyploid Heterosis in Nascent Hexaploid Wheat
Nascent allohexaploid wheat may represent the initial genetic state for the evolution and domestication of common wheat, which arose by combining the AB genomes of tetraploid Triticum turgidum with the D genome from Aegilops tauschii and out-competed its parents in growth vigor and adaptability. To ...
ORGANISM(S): Triticum dicoccon 
2014-10-20 | E-GEOD-56587 | biostudies-arrayexpress
ProteomicsPlatycodin D targeted proteomics
A proteomics work on Platycodin D targeting research
ORGANISM(S): Homo Sapiens 
2026-03-20 | PXD071858 |
ProteomicsMycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Interferon (IFN)-γ-producing CD8+ T cells are involved in control of Mycobacterium tuberculosis (Mtb) infection, in part by promoting antimicrobial activities of macrophages. Whether Mtb counters these responses, particularly during the hypoxic conditions that arise within granulomas during infectio...
ORGANISM(S): Mycobacterium tuberculosis OFXR-32 
2024-08-10 | PXD050258 | Pride
Mycobacterium tuberculosis  d-serine  rv0884c  wdr24  mtorc1  cd8+ t cell 
ProteomicsIDH1-mutant metabolite D-2-Hydroxyglutarate inhibits proliferation and sensitizes glioma to Temozolomide via down-regulating ITGB4/PI3K/AKT
The effects of D-2HG on U251 cells by conducting a proteomic analysis
ORGANISM(S): Homo Sapiens 
PXD052264 |
TranscriptomicsAnalysis of vitamin D response element binding protein target genes reveals a role for vitamin D in osteoblast mTOR signaling
Heterogeneous nuclear ribonucleoprotein (hnRNP) C1/C2 plays a pivotal role in vitamin D receptor (VDR) signaling by acting as a vitamin D response element (VDRE)-binding protein (VDRE-BP). Transcriptional regulation by active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) involves occupancy of VDRE by VDRE-...
ORGANISM(S): Homo sapiens 
2010-11-19 | E-GEOD-22523 | biostudies-arrayexpress
ProteomicsProteomics analysis of Polyphyllin D-treated triple-negative breast cancer cells reveal the anticancer mechanisms of Polyphyllin D
Polyphyllin D (PD) is the active component from an Asian traditional medicinal herb Paris polyphylla, and has been found to hold significant anticancer activity in vivo or in vitro. However, the mechanism through which PD exerts its anticancer effects in triple-negative breast cancer (TNBC) remains ...
ORGANISM(S): Homo Sapiens 
2023-03-20 | PXD040990 |
TranscriptomicsGenome-wide expression profiling of the response to D-limonene in Saccharomyces cerevisiae
Metabolic engineering of Saccharomyces cerevisiae for efficient monoterpenes production was mostly restricted by the limited tolerance to these chemicals. Understanding of the molecular mechanisms underlying the tolerance of S. cerevisiae to monoterpenes was essential for the de novo biosynthesis th...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-23 | E-GEOD-34665 | biostudies-arrayexpress
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