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ProteomicsImpaired AGO2/miR-185-3p/NRP1 Axis Promotes Colorectal Cancer Metastasis
Increasing evidence suggests that global downregulation of miRNA expression is a hallmark of human cancer, potentially due to defects in the miRNA processing machinery. In this study, we found that the protein expression of Argonaute 2 (AGO2), a key regulator of miRNA processing, was downregulated i...
ORGANISM(S): Homo Sapiens 
2021-02-11 | PXD024171 |
ProteomicsLactylation contributes to colorectal carcinogenesis
To reveal the lactylated proteins in CRC, we analyzed the lactyl-proteome from seven paired biopsies from CRC patients by using mass spectrometry analysis (LC-MS/MS). Meanwhile, we used LC-MS to identify Kla and Kac substrates upon HCT116 cells.
ORGANISM(S): Homo Sapiens 
2022-10-27 | PXD037744 |
MetabolomicsLipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectromet...

2017-04-26 | MTBLS352 | MetaboLights
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