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TranscriptomicsH3K9me3 CUT&RUN of mouse bone-marrow–derived macrophages and osteoclast precursors (RANKL-16h) from wild-type and Senp6 conditional knockout mice
To examine the impaired osteoclastogenic program in Senp6^LysM BMMs, we performed H3K9me3 CUT&RUN on WT and Senp6^LysM BMMs stimulated with RANKL for 16 h (R16) corresponding to sequential stages of early osteoclastogenesis.
ORGANISM(S): Mus musculus 
2026-09-28 | E-MTAB-17175 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse bone-marrow–derived macrophages and osteoclast precursors (BMM, RANKL-16h, RANKL-36h) from wild-type and Senp6 conditional knockout mice
To examine the impaired osteoclastogenic program in Senp6^LysM BMMs, we performed RNA-seq on WT and Senp6^LysM BMMs stimulated with RANKL for 0 h (R0), 16 h (R16), and 36 h (R36), corresponding to sequential stages of early osteoclastogenesis.
ORGANISM(S): Mus musculus 
2026-09-28 | E-MTAB-16140 | biostudies-arrayexpress
TranscriptomicsATAC-seq of mouse bone-marrow–derived macrophages and osteoclast precursors (BMM, RANKL-16h, RANKL-36h) from wild-type and Senp6 conditional knockout mice
To examine the impaired osteoclastogenic program in Senp6^LysM BMMs, we performed ATAC-seq on WT and Senp6^LysM BMMs stimulated with RANKL for 0 h (R0), 16 h (R16), and 36 h (R36), corresponding to sequential stages of early osteoclastogenesis.
ORGANISM(S): Mus musculus 
2026-09-28 | E-MTAB-16167 | biostudies-arrayexpress
ProteomicsLoss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP
The Ras GTPase-activating protein SynGAP interacts with PSD95 to regulate synaptic morphology and function at the postsynaptic density in neurons. Haploinsufficiency of SYNGAP1 has been linked to autism spectrum disorders (ASD) and intellectual disability (ID). While transcriptional and translationa...
ORGANISM(S): Mus Musculus 
2025-05-17 | PXD064040 |
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