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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsmiRNA profiling of double-positive thymocytes transduced with a retrovirus encoding Lin28a compared to untransduced controls
We used the NanoString mouse nCounter miRNA expression platform to compare the miRNA expression in double-positive (DP) thymocytes that developed in the presence (GFP+) or absence (GFP-ve) of ectopic mLin28 expression. Transduced (GFP+) and untransduced (GFP-ve) CD4+ CD8+ CD3- thymocytes were FACS s...
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-35081 | biostudies-arrayexpress
UnknownThe Na/K-ATPase α1 and c-Src form signaling complex under native condition: A crosslinking approach.
Not available
S-EPMC7138855 | biostudies-literature
TranscriptomicsTranscriptome of double-positive thymocyte precursors transduced with a retrovirus encoding Lin28a
We performed paired-end RNA-seq to compare the transcriptome of DP thymocytes that ectopically express Lin28 in vivo versus untransduced (GFP-ve) DP thymocytes. Transduced (GFP+) and untransduced (GFP-) CD4+ CD8+ CD3- thymocytes were sorted and pooled from three recipients of hematopoietic stem and ...
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-34854 | biostudies-arrayexpress
UnknownFollow-up of intraocular retinoblastoma through the quantitative analysis of conserved nuclear DNA sequences in aqueous humor from patients.
Not available
S-EPMC9732679 | biostudies-literature
UnknownCarbonylation Modification Regulates Na/K-ATPase Signaling and Salt Sensitivity: A Review and a Hypothesis.
Not available
S-EPMC4923243 | biostudies-literature
TranscriptomicsmicroRNA profiling of fetal liver and adult bone marrow pro-B cells
We used the NanoString mouse nCounter miRNA expression platform to compare the miRNA expression profiles of pro-B cells sorted from fetal liver and adult bone marrow in order to gain insight into changes in miRNA expression during B cell ontogeny. Fetal liver and adult bone marrow cells were harvest...
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-35107 | biostudies-arrayexpress
UnknownpNaKtide Inhibits Na/K-ATPase Signaling and Attenuates Obesity.
Not available
S-EPMC10812088 | biostudies-literature
UnknownThe Na/K-ATPase Oxidant Amplification Loop Regulates Aging.
Not available
S-EPMC6018655 | biostudies-literature
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