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TranscriptomicsAccelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low-Birth Weight Mice
OBJECTIVE: To characterize the hormonal milieu and adipose gene expression in response to catch-up growth (CUG), a growth pattern associated with obesity and diabetes risk, in a mouse model of low birth weight (LBW). RESEARCH DESIGN AND METHODS: ICR mice were food restricted by 50% from gestational ...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-16083 | biostudies-arrayexpress
TranscriptomicsAXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.
Phosphoinositide-3-kinase (PI3K)-α inhibitors are clinically active in squamous carcinoma (SCC) of the head and neck (H&N) bearing mutations or amplification of PIK3CA. We aimed to identify potential mechanism of resistance and have observed that SCCs cells overcome the antitumor effects of the PI3K...
ORGANISM(S): Homo sapiens 
2015-04-12 | E-GEOD-61515 | biostudies-arrayexpress
TranscriptomicsBaseline NSCLC cell lines compared to a reference mix consisting of 45 NSCLC cell lines
34 NSCLC cell lines were transcriptionally profiled against a reference mix of 45 NSCLC cell lines to look subtype specific differential gene expression 34 individual cell lines were compared to a reference mix consiting of 45 NSCLC cell lines
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-43567 | biostudies-arrayexpress
Transcriptomics8 NSCLC cell lines treated with either 50nM or 100nM of AUY for 24 hours.
RNA from treated cell lines are compared to RNA from matched untreated samples on the same chip to assess differential gene expression. RNA from treated cell lines are compared to RNA from matched untreated samples on the same chip to assess differential gene expression.
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-43568 | biostudies-arrayexpress
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