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Trichomes are the hair-like structures that are widely present on the surface of aerial organs and function in plant defense against biotic and abiotic stresses. Previous studies focus on the single cell trichomes in Arabidopsis and cotton, or multicellular glandular trichomes in tomato, but the dev...
ORGANISM(S): Cucumis sativus 
Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) remains a major clinical challenge in the targeted therapy of non-small cell lung cancer (NSCLC), yet its underlying mechanisms are poorly understood. The tumor microenvironment (TME), which provides a supportive n...
ORGANISM(S): Homo Sapiens 
We re-introduced Flag-mTRADD into Tradd-/- MEFs, and identified the phosphorylation sites of TRADD which were induced by TNF and inhibited by TAK1 inhibitor 5Z7 using mass spectrometry. We found that TAK1 could mediate the phosphorylation of multiple sites in TRADD upon TNF stimulation. We next perf...
ORGANISM(S): Homo Sapiens 
Metabolic imbalance drives organ aging and diseases, but the underlying mechanisms remain elusive. Here, we identify magnesium (Mg) deficiency as is a risk factor of gut health with age across species (human, primate, murine). Although Mg restriction had minimal effects in young mice, it exacerbated...
ORGANISM(S): Macaca Fascicularis Fascicularis Mus Musculus 
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