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TranscriptomicsGenome-wide profiling of gene expression under electro-acupuncture treatment on MI heart in rats
Purpose: Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI). In order to elucidate the potential mechanisms, RNA-seq by next generation sequencing was used to identify the rat genome-wide alterations after MI and EA treatment in t...
ORGANISM(S): Rattus norvegicus 
2016-03-21 | E-GEOD-54132 | biostudies-arrayexpress
TranscriptomicsHarnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis
Cell fate decisions depend on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2u Nucleosome Remodeling and Deacetylase (NuRD) complex is controlled by the Ikaros family of lymphoid-lineage determining proteins. Ikaros, an integral component ...
ORGANISM(S): Mus musculus 
2011-11-13 | E-GEOD-32311 | biostudies-arrayexpress
MetabolomicsLactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows

BACKGROUND: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the...

2018-03-16 | MTBLS411 | MetaboLights
TranscriptomicsIdentifying genes dysregulated in patients with acute myocardial infarction
Twenty-three AMI patients and 23 non-AMI healthy controls were included in this pilot study. Tissue samples were cut at 10 μm from formalin fixed paraffin-embedded tissue blocks using a microtome. Six to eight 10-μm sections were used for the isolation procedure. Total RNA isolation was performed us...
ORGANISM(S): Homo sapiens 
2016-05-11 | E-MTAB-3573 | biostudies-arrayexpress
TranscriptomicsGenes differentially expressed Haloarcula hispanica strains: PHB (M-NM-^TphaEC mutant) vs 960 (wild type)
Transcriptional profiling of Haloarcula hispanica comparing PHB with 960. PHB represents the PHA synthase genes mutant (i.e., M-NM-^TphaEC) which is deficient in PHBV accumulation when grown in MG medium. 960 represents the wild-type strain which can produce PHBV when grown in MG medium. Goal was to...
ORGANISM(S): Haloarcula hispanica 
2013-01-22 | E-GEOD-42799 | biostudies-arrayexpress
TranscriptomicsProgramming and inheritance of parental DNA methylomes in mammals
The reprogramming of parental methylomes is essential for embryonic development. In mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted to oxidized bases. These paternal oxidized bases and maternal 5mCs are believed to be passively diluted by cell divisions. By gen...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-56697 | biostudies-arrayexpress
UnknownDisease and disparity in China: a view from stroke and MI disease.
Not available
S-EPMC6558805 | biostudies-literature
TranscriptomicsSperm but not oocyte DNA methylome is inherited by zebrafish early embyros
5-methylcytosine is a major epigenetic modification sometimes called "the fifth nucleotide". However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes including zebrafish gametes and early embryos. The...
ORGANISM(S): Danio rerio 
2013-05-20 | E-GEOD-44075 | biostudies-arrayexpress
MetabolomicsComparative analysis of proteomic and metabolomic profiles of different species of Paris

An extract prepared from species of Paris is the most widely consumed herbal product in China. The genus Paris includes a variety of genotypes with different medicinal component contents but only two are defined as official sources. Closely related species have different medicinal properties beca...

2020-01-13 | MTBLS779 | MetaboLights
UnknownTargeted Metabolomics Provide Chemotaxonomic Insights of Medicago ruthenica, with Coupled Transcriptomics Elucidating the Mechanism Underlying Floral Coloration.
Not available
S-EPMC9505912 | biostudies-literature
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