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TranscriptomicsGene expression analysis of subcutaneous and omental adipose tissue from obese, insulin-resistant women
The association between central obesity and insulin resistance reflects the properties of visceral adipose tissue. Our aim was to gain further insight into this association by analysing the lipid composition of subcutaneous and omental adipose tissue in obese women with and without insulin resistanc...
ORGANISM(S): Homo sapiens 
2015-12-07 | E-GEOD-73108 | biostudies-arrayexpress
GenomicsGenome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [ChIP-Seq, MBD-Seq]
Purpose: The aim of this study is (1) to identify the chromatin occupancy of the epigenetic regulator Smchd1 in neural stem cells (NSCs) derived from E14.5 mouse brain; (2) to profile key epigenetic marks H3K4me3, H3K27me3 and DNA methylation in wild type and Smchd1 null NSCs; (3) to identify the ch...
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-65748 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [RNA-Seq]
Purpose: The aim of this study is to identify genes that are under the transcriptional control of the epigenetic regulator Smchd1 in neural stem cells (NSCs) derived from E14.5 mouse brain Methods: Total RNA was extracted using an AllPrep DNA/RNA Mini Kit (Qiagen) from cultured neural stem cells der...
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-65747 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-65749 | biostudies-arrayexpress
TranscriptomicsMolecular signature of brain resident memory CD8+ T cells
Tissue resident memory (Trm) represent a newly described memory T cell population. We have previously characterized a population of Trm that persists within the brain following acute virus infection. Although capable of providing marked protection against a subsequent local challenge, brain Trm do n...
ORGANISM(S): Mus musculus 
2012-08-29 | E-GEOD-39152 | biostudies-arrayexpress
ProteomicsMouse embryonic stem cells LCMS-MS
We hypothesized that uncovering interactions between Pfkp and other proteins could help resolve the mechanism whereby Pfkp regulates germ layer differentiation. Towards this, Pfkp was immunoprecipitated from mESCs and mass spectrometry analysis used to identify a number of potential Pfkp-interacting...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-23 | PXD038944 | Pride
Lcms-ms Mouse Embryonic stem cells 
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