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ProteomicsTargeting the UFL1-AKT Cascade Suppresses Triple-Negative Breast Cancer Progression
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease with limited therapeutic options. While UFL1-mediated UFMylation has been implicated in various diseases, its role in TNBC remains unexplored. In this study, we demonstrate that AKT1 directly interacts with UFL1 and unde...
ORGANISM(S): Homo sapiens (Human) 
2025-11-12 | PXD062168 | Pride
Ufl1 Triple-negative breast cancer Akt 
ProteomicsPharmacological Targeting of Casein Kinase 1δ Suppresses Oncogenic NRAS-Driven Melanoma
Activating mutations in NRAS account for 20-30% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator of oncogenic NRAS mutations, specifically Q61R and Q61K, which are the most prevalent NRAS mutations ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-20 | PXD046277 | Pride
Oncogenic nras melanomagenesis  melanoma progression ck1δ  usp46. 
ProteomicsSynthetic lethal combinations targeting PLK1-CBX8-GPX4 axis with BRAF and EGFR inhibition in BRAF V600E colorectal cancer
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and run into a bottleneck in the current treatment strategies. To identify regulatory pathways independent of the MAPK pathway in BRAFV600E CRC, we performed CRISPR-Cas9 screening, and and find targeting glutathione peroxidase 4 (GP...
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058213 |
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