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MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
UnknownIntegrated epigenetic biomarkers in circulating cell-free DNA as a robust classifier for pancreatic cancer.
Not available
S-EPMC7376965 | biostudies-literature
UnknownThe adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway.
Not available
S-EPMC8792011 | biostudies-literature
TranscriptomicsPtr-miR397a is a negative regulator of laccase genes affecting lignin content in Populus trichocarpa
Laccases were proposed to catalyze the oxidative polymerization of monolignols. We identified 49 laccase gene models in Populus trichocarpa, of which 29 were predicted to be targets of ptr-miR397a. We overexpressed Ptr-MIR397a in transgenic P. trichocarpa. In each of all 9 transgenic lines tested, 1...
ORGANISM(S): Populus trichocarpa 
2014-01-17 | E-GEOD-54153 | biostudies-arrayexpress
UnknownCX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies.
Not available
S-EPMC10105289 | biostudies-literature
UnknownInhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.
Not available
S-EPMC6796588 | biostudies-literature
TranscriptomicsmiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse somatic cells
To reprogram mouse embryonic fibroblasts (MEFs) to induced Pluripotent Stem Cells (iPSCs), we constructed the PiggyBac (PB) transposon carrying the four Yamanaka factor cDNAs controlled by a CAG promoter (PB-CAG-OCKS, Oct4, cMyc, Klf4 and Sox2). As the baseline reprogramming control, we transfected ...
ORGANISM(S): Mus musculus 
2011-10-10 | E-MTAB-409 | biostudies-arrayexpress
UnknownCombining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.
Not available
S-EPMC7426242 | biostudies-literature
UnknownEndothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier.
Not available
S-EPMC10067974 | biostudies-literature
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