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Germline mutations in LKB1 (STK11) are associated with the Peutz–Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma. By somatically inactivating Lkb1 with K-Ras activation (+/- p53 loss) in murine melanocytes, we ...
ORGANISM(S): Mus musculus 
This study established, for the first time, a system for extracting water-soluble active proteins from the cocoon layers of multiple pigmented silkworm varieties and systematically evaluated their consistent antioxidant activities together with variety-specific antimicrobial functions. DIA-based pro...
ORGANISM(S): Bombyx Mori 
2026-03-30 | PXD076347 |
HDCA supplementation ameliorated diet-induced NAFLD in C57 wild type mice. In attempt to comprehensively understand the molecular mechanism occurring during the protective effect of HDCA, transcriptomic and proteomic profiles of mouse liver were first analyzed utilizing RNA-Sequencing and Tandem Mas...
ORGANISM(S): Mus Musculus 
2023-08-18 | PXD044613 |
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