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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
TranscriptomicsDigital gene expression analysis reveals genes associated with hexythiazox resistance in citrus red mite, Panonychus citri
We compared a miticides resistant strain and a susceptible strain's gene expression profile to reveal genes associated with miticide resistance in Panonychus citri.
ORGANISM(S): Panonychus citri 
2013-06-11 | E-MTAB-1193 | biostudies-arrayexpress
MetabolomicsGut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-f...
2022-04-01 | MTBLS4431 | MetaboLights
ProteomicsLoss of Drosophila nucleostemin 1 disrupts ribosomal protein homeostasis and rRNA processing to trigger apoptosis via the Xrp1/Irbp18 complex
In this study, we investigate the role of Ns1 in proliferating epithelial tissues using the Drosophila wing imaginal disc as a model. We demonstrate that knocking down Ns1 in wing discs leads to strong apoptosis. However, unlike the reported effect on overexpressed RPs, we did not observe nucleolar ...
ORGANISM(S): Drosophila Melanogaster 
2026-03-02 | PXD075076 |
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