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MetabolomicsUntargeted Metabolomics of the enthesis interstitial fluid of wild-type and Nlrp3-/- mice with sham operation and injury post 7 days
In order to investigate the effect of the NLRP3 inflammasome on the regeneration of enthesis, we established an enthesis injury and repair model in wild-type and NLRP3-/- mice. The interstitial fluid of enthesis was extracted, and untargeted metabolomics was conducted to discover differential metabo...
2025-07-08 | MTBLS12150 | MetaboLights
ProteomicsHsp17.4 mediates salicylic acid and jasmonic acid pathways in the regulation of resistance to strawberry anthracnose
Our previous study found that the expression of HSP17.4 is closely related to the occurrence of strawberry anthracnose. In this study, we used virus-mediated gene silencing technology and found that the HSP17.4 gene-silenced ‘Sweet Charlie’ plants were more susceptible to Colletotrichum gloeosporioi...
ORGANISM(S): Fragaria Vesca Subsp. Vesca 
2021-01-09 | PXD023494 |
TranscriptomicsPulmonary alveolar macrophages (PAMs) of Tongcheng piglets response to HP-PRRSV infection in vivo
Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), is the most economically important disease in pig populations. Lung damage is one major pathological condition following PRRSV infection, often leading to animal death. In vivo, PRRSV productive infection occurs pred...
ORGANISM(S): Sus scrofa 
2012-06-30 | E-GEOD-22782 | biostudies-arrayexpress
ProteomicsGPX4 immunoprecipitation in Huh7 cells
Huh7 cells with expression of Flag-GPX4 were treated with IGF1. An immunoprecipitation assay was performed, and immunoprecipitates were subjected to masspec analysis.
ORGANISM(S): Human 
2023-02-22 | MSV000091343 | MassIVE
UnknownA non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres
Not available
S-SCDT-10_1038-S44318-024-00104-6 | biostudies-other
MetabolomicsUntargeted metabolites of supernatant of wild-type and Nlrp3-/- bone marrow-derived macrophages with or without LPS and ATP costimulation
Untargeted metabolites of supernatant of wild-type and Nlrp3-/- bone marrow-derived macrophages without stimulation or with 4 hours of LPS preconditioning and subsequently 30 min of ATP stimulation.
2025-07-08 | MTBLS12152 | MetaboLights
TranscriptomicsMutated RNA component of the telomerase induces apoptosis via GADD45-? in hTERT-overexpressing primary fibroblasts
Mutant template human telomerase RNAs (MT-hTers) have been shown to induce apoptosis in various cancerous cells that have high telomerase activity. However, the exact mechanisms by which MT-hTers inhibit the growth of cancer cells and affect normal somatic cells remain largely unknown. To determine ...
ORGANISM(S): Homo sapiens 
2011-05-28 | E-GEOD-24975 | biostudies-arrayexpress
TranscriptomicsInvestigation of extra-telomeric effects of hTERT in neoplastic transformation of IMR90 cells
The complexity and heterogeneity of cancer cells are under-represented by the current experimental models which revolve around primary tumor cells, cancer cell lines, and rodent models. We used the transformed cell model in our studies. IMR90 and BJ fibroblast cells were transformed by three oncogen...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-24097 | biostudies-arrayexpress
ProteomicsDual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation (1)
Copper (Cu) performs essential structural and functional roles in all aerobic organisms, but identifying natural cuproproteins through traditional affinity methods is hindered by the variety of copper ligand combinations and binding locations in proteins. Here, using ATOX1 as a bait, fused with the ...
ORGANISM(S): Homo Sapiens 
PXD068622 |
ProteomicsDual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation (2)
Copper (Cu) performs essential structural and functional roles in all aerobic organisms, but identifying natural cuproproteins through traditional affinity methods is hindered by the variety of copper ligand combinations and binding locations in proteins. Here, using ATOX1 as a bait, fused with the ...
ORGANISM(S): Homo Sapiens 
PXD068649 |
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