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MetabolomicsBifidobacterium bifidum-derived nanoparticles attenuate alcoholic liver disease via enhanced hepatic phagocytosis and gastrointestinal homeostasis
Alcohol-associated liver disease (ALD) has limited therapeutic options due to its complex pathogenesis. This study demonstrates the ALD-protective effects of extracellular nanoparticles derived from Bifidobacterium bifidum (BNPs), focusing on the novel concept of gut microbiota-derived nanoparticles...
2025-06-19 | MTBLS12612 | MetaboLights
MetabolomicsFitm2 is required for ER homeostasis and normal function of murine liver
Not available
ORGANISM(S): Mus musculus 
ST002303 | MetabolomicsWorkbench
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
MetabolomicsOregano essential oil improves growth performance and health of steers by maintaining gut-liver axis homeostasis through the ileal microbiota-mediated bile acid pathway

The high-concentrate diet presents significant challenges regarding intestinal nutrient absorption and hepatic energy metabolism in beef cattle. Therefore, it is crucial to develop novel intervention strategies to solve it. This study examined the effects of oregano essential oil (OEO) on the gro...

2026-03-26 | MTBLS14146 | MetaboLights
MetabolomicsIntegrated multi-omics analysis of liver metabolic dysregulation in ACE2 knockout mice
This study systematically investigated the impact of ACE2 knockout (ACE2KO) on hepatic metabolic homeostasis and its molecular mechanisms, using integrated transcriptomic, proteomic, and metabolomic profiling. ACE2 deficiency exacerbates hepatic lipid accumulation, as evidenced by elevated total cho...
2025-06-23 | MTBLS12389 | MetaboLights
MetabolomicsMulti-Organ Metabolomic and Ionomic Characterization of Chronic Alcohol Exposure-Induced Alcoholic Liver Disease
Background: Alcoholic liver disease (ALD) is a prevalent chronic liver disorder worldwide. Chronic alcohol exposure not only damages the liver but also disrupts metabolic and elemental homeostasis in multiple organs. However, its systemic effects remain incompletely understood. This study used an in...
2026-10-08 | MTBLS15954 | MetaboLights
MetabolomicsPenthorum chinense Pursh Ameliorates Metabolic Dysfunction-Associated Alcohol-Related Liver Disease through Gut Microbiota Modulation and Metabolic Remodeling
Metabolic dysfunction-associated alcohol-related liver disease (MetALD) is characterized by hepatic steatosis, oxidative stress, inflammation, and gut microbiota dysbiosis resulting from the coexistence of metabolic dysfunction and alcohol consumption. Penthorum chinense Pursh is a traditional edibl...
2026-06-10 | MTBLS14735 | MetaboLights
MetabolomicsThe GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis
Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue specific methyltransferases regulates methylation potential. Among them,...
2026-08-18 | MTBLS15161 | MetaboLights
TranscriptomicsMOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Illumina)
In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients providing a proof-of-principle that allograft tolerance is attainable in humans. The intra-graft molecular pathways associated with human allograft tolerance, how...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-26625 | biostudies-arrayexpress
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