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MetabolomicsFasting wildtype, tfeb -/- knockout, and lmna -/- knockout metabolite profiling of adult zebrafish
Not available
ORGANISM(S): Danio rerio 
ST000584 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse heart samples from individuals with homozygous or heterozygous mutant alleles of Lamin A (LMNA)
This SuperSeries is composed of the following subset Series:; GSE6397: Comparison between gene expression in heart from Lmna H222P heterozygous and control mice; GSE6398: Comparison between gene expression in heart from Lmna H222P homozygous and control mice Experiment Overall Design: Refer to indiv...
ORGANISM(S): Mus musculus 
2007-10-31 | E-GEOD-8000 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse heart from Lmna H222P heterozygous and control mice
The present research is devoted to the identification of gene(s) severely affected by LMNA mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Lmna H222...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6397 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart from Lmna H222P homozygous and control mice
The present research is devoted to the identification of gene(s) severely affected by LMNA mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Lmna H222...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6398 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of liver samples from Lmna Gly609Gly knock-in mice
Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by a point mutation in the LMNA gene that activates a cryptic donor splice site and yields a truncated form of prelamin A called progerin. Small amounts of progerin are also produced during normal aging. Studies with mouse models of HGPS have all...
ORGANISM(S): Mus musculus 
2012-01-13 | E-GEOD-32609 | biostudies-arrayexpress
ProteomicsProteomics reveals mitochondrial dysfunction in Lmna-/- mice hearts
We performed proteomics analysis on Lmna-/- hearts from mice at 2 weeks and 1 month of age to investigate the underlying mechanism by which LMNA deletion evokes DCM
ORGANISM(S): Mus Musculus 
2023-06-25 | PXD043270 |
GenomicsATAC-seq data from Lmna knock-out mouse embryonic fibroblasts (Lmna-/- MEFs) and wild type (Lmna+/+ MEFs)
ATAC-seq data from Lmna knock-out mouse embryonic fibroblasts (Lmna-/- MEFs) and wild type (Lmna+/+ MEFs)
PRJNA775055 | ENA
TranscriptomicsGene expression profile in Lmna knockout mouse embryonic fibroblast
Alteration of gene expression profile due to Lmna knockout was studied in MEF. Total RNA obtained from Lmna +/+ MEF and Lmna -/- MEF were compared.
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-38777 | biostudies-arrayexpress
TranscriptomicsExpression data from E161K LMNA mutant heart and control
Over 180 LMNA gene mutations have been identified in human diseases including cardiac and skeletal myopathies, lipodystrophies, and premature aging syndromes. Postulated mechanisms by which these mutations result in different phenotypes include perturbation of normal nuclear structure and chromosom...
ORGANISM(S): Homo sapiens 
2010-01-30 | E-GEOD-17476 | biostudies-arrayexpress
GenomicsCardiomyocyte-specific lamin A re-expression via AAV-Lmna/DJ8 ameliorates cardiac dysfunction in Lmna⁻/⁻ mice
Cardiomyocyte-specific lamin A re-expression via AAV-Lmna/DJ8 ameliorates cardiac dysfunction in Lmna⁻/⁻ mice
PRJNA1423655 | ENA
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