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ProteomicsIdentification of lncRNA CALA-dependent protein interaction partners of G3BP1 in the cytoplasm
We previously identified the stimuli-responsive lncRNA CALA to impact endothelial cell function and identified G3BP1 as a main interaction partner of CALA in the cytoplasm of human umblical vein endothelial cells (HUVECs). To uncover the role of the lncRNA CALA in G3BP1-RNPs in the cytoplasm, we pur...
ORGANISM(S): Homo sapiens (Human) 
2022-07-04 | PXD033517 | Pride
Lncrna-dependent protein/protein interaction 
ProteomicsEndothelial protein interaction partners of the lncRNA PCAT19
PCAT19 is an endothelial-enriched lncRNA that contributes to the proliferation-quiescence switch in a cell density-dependent manner. Here we performed an antisense-oligonucleotide pulldown of the PCAT19 lncRNA followed by mass spectrometry to identify protein interaction partners of PCAT19. Interact...
ORGANISM(S): Homo sapiens (Human) 
2022-09-29 | PXD032669 | Pride
Pcat19 Proteome Lncrna Cell cycle Endothelial 
TranscriptomicsWidespread N6-methyladenosine-dependent RNA Structural Switches Regulate RNA-Protein Interactions
We show that N6-methyladenosine (m6A), the most abundant internal modification in mRNA/lncRNA with still poorly characterized function, alters RNA structure to facilitate the access of RBM for heterogeneous nuclear ribonucleoprotein C (hnRNP C). We term this mechanism m6A-switch. Through combining P...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-56010 | biostudies-arrayexpress
UnknownIdentification of lncRNA functions in lung cancer based on associated protein-protein interaction modules.
Not available
S-EPMC5081511 | biostudies-literature
GenomicsOn the discovery of ADRAM, an experience-dependent long noncoding RNA that drives fear extinction though direct interaction with the chaperone protein 14-3-3
On the discovery of ADRAM, an experience-dependent long noncoding RNA that drives fear extinction though direct interaction with the chaperone protein 14-3-3
PRJNA753078 | ENA
TranscriptomicsA SWI/SNF nucleosome remodeling complex acts in non-coding RNA-mediated transcriptional silencing
RNA-mediated transcriptional silencing prevents deleterious effects of transposon activity and controls the expression of protein-coding genes. It involves long non-coding RNAs (lncRNAs)1, which in Arabidopsis thaliana are produced by a specialized RNA Polymerase V (Pol V)2. lncRNAs guide Argonaute-...
ORGANISM(S): Arabidopsis thaliana 
2012-12-01 | E-GEOD-38400 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNA as regulatory switch of protein turnover
Long intervening noncoding RNAs (lincRNAs) are prevalent genes with poorly understood functions. Here we discover a pathway of lincRNA-regulated proteolysis. The enhancer-like lincRNA HOTTIP extends the half-life of its binding protein WDR5, a subunit of the MLL H3K4 methylase complex, resulting in ...
ORGANISM(S): Mus musculus 
2013-02-18 | E-GEOD-36513 | biostudies-arrayexpress
GenomicsOn the discovery of ADRAM, an experience-dependent long noncoding RNA that drives fear extinction though direct interaction with the chaperone protein 14-3-3
Long-noncoding RNA (lncRNA) comprise a new class of genes that have been assigned key roles in development and disease. Many lncRNAs are specifically transcribed in the brain where they regulate the expression of protein-coding genes that underpin neuronal function; however, their role in learning a...
ORGANISM(S): Mus musculus 
2021-12-31 | GSE181706 | GEO
UnknownIdentification of novel PANDAR protein interaction partners involved in splicing regulation.
Not available
S-EPMC5809411 | biostudies-literature
TranscriptomicsA long noncoding RNA protects the heart from pathological hypertrophy
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo antisense transcription1, including myosin heavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction2. Her...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49716 | biostudies-arrayexpress
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