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GenomicsHuman Pancreatic Beta Cell lncRNAs Control Cell-Specific Regulatory Networks
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cel...
EGAS00001002865 | EGA
TranscriptomicsCharacterization of stress-responsive lncRNAs in Arabidopsis thaliana
We sequenced the total RNA from a tissues mixed sample (inflorescences, rosette leaves, cauline leaves and stems) of Arabidopsis thaliana. After total RNA extraction, the same amount of tissue RNA were mixed. Ribosomal RNAs were deleted from the mixed tissue total RNAs using RiboMinus™ Plant Kit rep...
ORGANISM(S): Arabidopsis thaliana 
2014-09-18 | E-GEOD-49325 | biostudies-arrayexpress
TranscriptomicsSenescence-associated lncRNAs: senescence-associated long noncoding RNAs.
Noncoding RNAs include small transcripts, such as microRNAs and piwi-interacting RNAs, and a wide range of long noncoding RNAs (lncRNAs). Although many lncRNAs have been identified, only a small number of lncRNAs have been characterized functionally. Here, we sought to identify lncRNAs differentiall...
ORGANISM(S): Homo sapiens 
2016-02-08 | E-GEOD-77675 | biostudies-arrayexpress
ProteomicsComputational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human
Functional studies of long noncoding RNAs (lncRNAs) have long been hindered by a lack of methods to assess their evolution. Here, we present lncHOME (lncRNA Homology Explorer), a computational pipeline that identifies a unique coPARSE-lncRNA class with conserved genomic locations and patterns of RNA...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Homo sapiens (Human) Mus musculus (Mouse) 
2024-01-26 | PXD046452 | Pride
Mouse Human Zebrafish Rbp Lc-ms/ms 
TranscriptomicsAberrant expression of lncRNAs in autistic brain
To assess for the potential contribution of dysregulated long non-coding RNA expression in autism pathogenesis, we profiled lncRNAs and mRNAs from post mortem brain tissue from autism patients and age/sex matched controls 4 brain tissue samples from autism patients (2 patients, 1 prefrontal cortex a...
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-36315 | biostudies-arrayexpress
TranscriptomicsLncRNAs expression profiles in the livers of C57Bl/6 mice after partial hepatectomy
Liver regeneration has important implications because many therapeutic strategies for the surgical treatment of liver diseases, such as removal of liver tumors and liver transplantation, depend on the ability of the liver to regenerate physically and functionally. Recent studies reported that lncRNA...
ORGANISM(S): Mus musculus 
2013-04-24 | E-GEOD-43687 | biostudies-arrayexpress
TranscriptomicsScreening and validation of lncRNAs and circRNAs as miRNA sponges [siRNA, miRNA-2_0]
Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are collectiv...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-73689 | biostudies-arrayexpress
TranscriptomicsScreening and validation of lncRNAs and circRNAs as miRNA sponges [cell lines, miRNA-2_0]
Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are collectiv...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-73690 | biostudies-arrayexpress
TranscriptomicsIdentification and functional characterization of long noncoding RNAs in breast cancer
In this study, we have integrated RNA-seq data from subcellular fractionated RNA (i.e., cytoplasm, nucleoplasm, and chromatin-associated) with GRO-seq data using a novel bioinformatics pipeline. This has yielded a comprehensive catalog of polyadenylated lncRNAs in MCF-7 cells, about half of which ha...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-63189 | biostudies-arrayexpress
TranscriptomicsScreening and validation of lncRNAs and circRNAs as miRNA sponges [siRNA, HuGene-1_0-st]
Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are collectiv...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-73683 | biostudies-arrayexpress
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