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TranscriptomicsMicroRNA-674-5p/5-LO axis is important in concanavalin A-induced acute mouse liver injury
Eight-week-old male pathogen-free BALB/c mice were used for the induction of concanavalin A (Con A)-induced hepatitis. Animals were acclimated for at least 6-7 days to a 12-hour light/dark cycle in a humidity- and temperature-controlled, specific-pathogen-free environment in autoclaved cages. Mice w...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-76345 | biostudies-arrayexpress
MetabolomicsRabbit plasma metabolomic analysis of Nitroproston: a multi target natural prostaglandin based-drug (Untargeted study)
INTRODUCTION: Nitroproston® is a novel multi-target drug bearing natural prostaglandin E2 (PGE2) and nitric oxide (NO)-donating fragments for treatment of inflammatory and obstructive diseases (i.e. asthma and obstructive bronchitis). OBJECTIVES: To investigate the effects of Nitroproston® adm...
2019-08-27 | MTBLS727 | MetaboLights
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
Metabolomics3D DESI mass spectrometry imaging of 51 serial sections from a human liver metastasis
51 serial sections from a single human liver metastasis are made available in this dataset. Four neighbouring sections were placed on a single slide and analysed together. The tissue sections were analysed by desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) according to the pr...
2016-04-28 | MTBLS282 | MetaboLights
MetabolomicsSexual dimorphism in the gonad lipidome of blue mussels (Mytilus sp.): New insights from a global lipidomics approach

Blue mussels (Mytilus sp.) are an economically important species for European aquaculture. Their importance as a food source is expected to increase in the coming net-zero society due to their low environmental footprint; however, their production is affected by anthropogenic stressors and climat...

2024-11-08 | MTBLS8492 | MetaboLights
GenomicsSoil samples of Lo encanada
Soil samples of Lo encanada Raw sequence reads
PRJNA805231 | ENA
ProteomicsExploring CD26-/lo subpopulations of lymphocytes in asthma phenotype and severity: a novel CD4+ T cell subset expressing archetypical granulocyte proteins.
Different naïve or memory cell subpopulations (i.e., central memory/CM, effector memory/EM, or terminally differentiated effector memory/EMRA) are involved in asthma development, and they display variable levels of the CD26 (dipeptidyl peptidase 4/DPP4). The phenotype and/or severity of the disease ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-17 | PXD051222 | Pride
Clustering Asthma Effector memory T helper Cd26 Lymphocytes 
UnknownHuman CD34(lo)CD133(lo) fetal liver cells support the expansion of human CD34(hi)CD133(hi) hematopoietic stem cells.
Not available
S-EPMC5037276 | biostudies-literature
MetabolomicsLipid mediators of inflammation in BALF 3-11 days after infection with influenza
Bioactive lipid mediators play a crucial role in the induction and resolution of inflammation. To elucidate their involvement during influenza infection, liquid chromatography/mass spectrometry lipidomic profiling of 141 lipid species was performed on a mouse influenza model using two viruses of sig...
2013-05-30 | MTBLS33 | MetaboLights
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