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TranscriptomicsPRMT1 interacts with leukemia fusion protein AML1-ETO for activation of transcription and transformation
Fusion protein AML1-ETO resulted from t(8;21) translocation is highly related to leukemia development. We have previously shown that the expression of AE9a, a spliced form of AML1-ETO, can rapidly cause leukemia in mouse. To understand how AML1-ETO is involved in leukemia development, we used AE9a l...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-28135 | biostudies-arrayexpress
TranscriptomicsExpression profiling of primary leukemia initiating cell-enriched population induced by AML1-ETO9a
Combined gene expression and DNA occupancy profiling identifies JAK/STAT signaling as a valid therapeutic target of t(8;21) AML t(8;21) is commonly associated with acute myeloid leukemia (AML). The resulting AML1-ETO fusion proteins are involved in the pathogenesis of AML. To identify novel molecul...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-15195 | biostudies-arrayexpress
UnknownGenome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Not available
S-EPMC4549775 | biostudies-literature
UnknownAssociation analysis identifies 65 new breast cancer risk loci.
Not available
S-EPMC5798588 | biostudies-literature
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