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ProteomicsDeciphering the logic of mammalian mitochondrially-localised translation
Localised translation broadly enables spatiotemporal control of gene expression yet currently there are limited tools for monitoring subcellular translation in mammalian cells. Here we present LOCL-TL (LOV-domain Controlled Ligase for Translation Localisation) an optogenetic approach for labelling r...
ORGANISM(S): Homo sapiens (Human) 
2025-07-29 | PXD054646 | Pride
Human Mitochondria Localised translation 
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75247 | biostudies-arrayexpress
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75410 | biostudies-arrayexpress
TranscriptomicsHuman Staufen1 associates to miRNAs involved in neuronal cell differentiation and is required for correct dendritic formation
Double-stranded RNA-binding proteins are key elements in the intracellular localization of mRNA and its local translation. Staufen is a double-stranded RNA binding protein involved in the localised translation of specific mRNAs during Drosophila early development and neuronal cell fate. The human ho...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-61732 | biostudies-arrayexpress
GenomicsTranslation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames. To address this question, we performed ribosome profiling of 32 medullob...
EGAS00001007426 | EGA
UnknowneIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
Not available
S-EPMC9976904 | biostudies-literature
TranscriptomicsTranscriptome-wide identification of LIN28A targets in mouse embryonic stem cell (A3-1) [Illumina Seq]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37111 | biostudies-arrayexpress
TranscriptomicsTranscriptome partitioning for mRNA translation in hypoxia
Protein synthesis belongs to the most energy consuming processes in the cell. Lowering oxygen tension below normal (hypoxia) causes a rapid inhibition of global mRNA translation due to the decreased availability of energy. Interestingly, subsets of mRNAs pursue active translation under such circumst...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-49029 | biostudies-arrayexpress
UnknownTwo oppositely localised frizzled RNAs as axis determinants in a cnidarian embryo.
Not available
S-EPMC1820609 | biostudies-literature
TranscriptomicsGenome-wide translational analysis of the effect of acute endurance exercise on mouse gastrocnemius
Purpose: The aim of this study is to investigate the translational regulation of skeletal muscle during acute endurance exercise. Methods: We used mRNA-Seq and ribosome profiling to examine transcriptional and translational regulation, respectively. Result: There were clear distinctions between the ...
ORGANISM(S): Mus musculus 
2016-02-16 | E-GEOD-69699 | biostudies-arrayexpress
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