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TranscriptomicsTranscriptional interaction network analyses in dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra in Parkinson's disease
We analyzed the transcriptomic profile of post-mortem explants from dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra obtained from controls and Braak 4 (BK4) and 5 (BK5) stages of Parkinson’s disease (PD) patients in order to investigate how gene-gene interaction patterns vary alo...
ORGANISM(S): Homo sapiens 
2015-01-11 | E-GEOD-43490 | biostudies-arrayexpress
ProteomicsSex Differences in Single Neuron Function and Proteomics Profiles Examined by Patch-Clamp and Mass Spectrometry in the Locus Coeruleus of the Adult Mouse
Aims: This study aimed to identify and characterize the intrinsic properties of locus coeruleus (LC) noradrenergic neurons in male and female mice using a genetic approach. We also sought to investigate sex-specific differences in membrane properties, action potential generation, and protein express...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD045844 | Pride
Neuronal excitability Single-cell proteomics Noradrenergic neurons Locus coeruleus Sex-differences 
ProteomicsPathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of prodromal Alzheimer’s disease
Alzheimer’s disease (AD), though defined as a cognitive disorder, often presents neuropsychiatric symptoms such as anxiety, depression, agitation and sleep disruptions years before the onset of frank memory impairment. A hallmark prodromal feature is the accumulation of hyperphosphorylated “pretangl...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-22 | PXD071656 | Pride
Alzheimer’s disease Locus coeruleus (lc) 
GenomicsLocus coeruleus vulnerability to tau hyperphosphorylation in a rat model
Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model
PRJNA1138745 | ENA
GenomicsSingle-nuclei RNA sequencing of the locus coeruleus and pericoerulear brain regions
Single-nuclei RNA sequencing of the locus coeruleus and pericoerulear brain regions
PRJNA834021 | ENA
GenomicsSex and life experience shape locus coeruleus pretangle tau pathology
Sex and life experience shape locus coeruleus pretangle tau pathology
PRJNA1309729 | ENA
GenomicsCellular Signatures of Melanocortin Pathway Genes Across the Locus Coeruleus [Spatial Transcriptomics]
Cellular Signatures of Melanocortin Pathway Genes Across the Locus Coeruleus [Spatial Transcriptomics]
PRJNA1450713 | ENA
GenomicsCellular Signatures of Melanocortin Pathway Genes Across the Locus Coeruleus [snRNA-seq]
Cellular Signatures of Melanocortin Pathway Genes Across the Locus Coeruleus [snRNA-seq]
PRJNA1450711 | ENA
TranscriptomicsSingle-nuclei RNA sequencing of the locus coeruleus and pericoerulear brain regions
As the primary source of norepinephrine (NE) in the brain, the locus coeruleus (LC) regulates both arousal and stress responses, but how neuromodulatory inputs contribute to LC modulation remains incompletely understood. In this study, we isolated a network of transcriptionally diverse inhibitory pe...
ORGANISM(S): Mus musculus 
2025-01-31 | GSE201998 | GEO
UnknownActive control of arousal by a locus coeruleus GABAergic circuit.
Not available
S-EPMC6385895 | biostudies-literature
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