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TranscriptomicsHIF-1synergizes with glucocorticoids to promote BFU-E progenitor self-renewal
With the aim of finding small molecules that stimulate erythropoiesis earlier than erythropoietin and that enhance CFU-E production, we studied the mechanism by which glucocorticoids increase CFU-E formation. Using BFU-E and CFU-E progenitors purified by a new technique, we demonstrate that glucocor...
ORGANISM(S): Mus musculus 
2010-12-21 | E-GEOD-26086 | biostudies-arrayexpress
TranscriptomicsDownregulation of Myc is essential for terminal erythroid maturation
Terminal differentiation of mammalian erythroid progenitors involves 4-5 cell divisions and induction of many erythroid important genes, followed by chromatin and nuclear condensation and enucleation. The protein levels of c-myc (Myc) are reduced dramatically during late stage erythroid maturation, ...
ORGANISM(S): Mus musculus 
2010-10-13 | E-GEOD-18558 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNAs regulate adipogenesis (Affymetrix)
Adipogenesis involves the regulation of hundreds of genes by several well-studied proteins, but the role of long, noncoding RNAs in this process has not been defined. We track the regulation of hundreds of lncRNAs during adipocyte differentiation, and find several that are essential for this proces...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-29897 | biostudies-arrayexpress
GenomicsCTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-06-27 | E-GEOD-67893 | biostudies-arrayexpress
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