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GenomicsMapping polycomb complexes in human and mouse embryonic stem cells
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2000 genes. To gain insight into the structure and function of bivalent domains, we m...
ORGANISM(S): Mus musculus 
2008-11-01 | E-GEOD-13084 | biostudies-arrayexpress
UnknownAdvanced Glycation End Products Mediate Epigenetic Alteration of H3K27me3 in Renal Proximal Tubular Cells: Potential Role in Metabolic Memory.
Not available
S-EPMC12607550 | biostudies-literature
TranscriptomicsDissection of human embryonic stem cells-derived endoderm progenitors by differential cell capture on antibody arrays
Heterogeneity, shortage of material, and lack of progenitor-specific cell surface markers are major obstacles to elucidating the mechanisms underlying developmental processes. Here we report a proteomic platform that alleviates these difficulties and demonstrate its effectiveness in fractionating he...
ORGANISM(S): Homo sapiens 
2012-12-29 | E-GEOD-34075 | biostudies-arrayexpress
TranscriptomicsKMT2D haploinsufficiency in Kabuki Syndrome disrupts neuronal function through transcriptional and chromatin rewiring independent of H3K4-monomethylation
Kabuki Syndrome (KS) is a multisystemic rare disorder, characterized by growth delay, distinctive facial features, intellectual disability, and rarely autism spectrum disorder. This condition is mostly caused by de novo mutations of KMT2D, encoding a catalytic subunit of the COMPASS complex involved...
ORGANISM(S): Homo sapiens 
2022-12-25 | E-MTAB-10244 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of the effects of a parasitic nematode's secreted exosomes on mammalian cells.
We show that a gastrointestinal nematode that infects mice, Heligmosomoides polygyrus, secretes vesicles packaged with specific microRNAs (miRNAs) and Y RNAs as well as a nematode-specific Argonaute protein. The vesicles are of intestinal origin and are enriched for homologs of mammalian proteins fo...
ORGANISM(S): Mus musculus 
2014-12-24 | E-GEOD-55941 | biostudies-arrayexpress
TranscriptomicsSequential stage specific reporter line analysis (SSRLA) of 3 BAC transgenic mESC lines
FACS purified cells from differentiation day 14-15 cells from 3 BAC transgenic mESC lines: Hes::GFP (early), Nurr1::GFP (mid), and Pitx3::YFP (late) DA neuron development reporter lines All three lines were differentiated towards the midbrain dopamine phenotype, and FACS purification was performed ...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37446 | biostudies-arrayexpress
GenomicsChIP-Seq of human embryonic stem cells of a differentiation time course with antibody against H3K4me3
H3K4me3 ChIP-Seq profiling of a directed differentiation time course converting human embryonic stem cells (hES) into immature pancreatic beta cell precursors. CyT49, a Viacyte proprietary male hESC line with normal karyotype was used.
ORGANISM(S): Homo sapiens 
2012-10-13 | E-MTAB-821 | biostudies-arrayexpress
TranscriptomicsExpression data from Min6 cells maintained under different culture conditons that affect Hes3 expression and localization
The basic helix-loop-helix (bHLH) transcription factor hairy and enhancer of split (Hes3) is a member of the Hes/Hey gene family that regulates developmental processes in progenitor cells from various tissues. We demonstrated the Hes3 expression in mouse pancreatic tissue, suggesting it may have a r...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-64444 | biostudies-arrayexpress
TranscriptomicsGene expression data from Min6 cells grown in serum containing and serum free condtions following Hes3 knock down
The basic helix-loop-helix (bHLH) transcription factor hairy and enhancer of split (Hes3) is a member of the Hes/Hey gene family that regulates developmental processes in progenitor cells from various tissues. We demonstrated the Hes3 expression in mouse pancreatic tissue, suggesting it may have a r...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-64449 | biostudies-arrayexpress
UnknownRegional sepsis care in Catalonia: comparative insights from a secondary analysis of the European Sepsis Care Survey.
Not available
S-EPMC12366016 | biostudies-literature
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