Pancreatic ductal adenocarcinoma (PDAC) cells rely on glutamine to sustain their survival and growth in their stiff, hypoxic tumour microenvironment (TME). Inhibiting the glutamate oxaloacetate transaminase 1 (GOT1) enzyme is a promising strategy to target glutamine metabolism and impair PDAC cell f...
ORGANISM(S): Homo sapiens (Human)
