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ProteomicsMulti-omics analysis reveals the sensitivity of immunotherapy for unresectable non-small cell lung cancer
Peripheral blood plasma was collected from unresectable stage III and IV non-small cell lung cancer patients who were negative for driver mutations before receiving immunotherapy. Then we classified samples according to the follow-up results after two courses of immunotherapy and non-targeted metabo...
ORGANISM(S): Homo Sapiens 
2024-12-18 | PXD058967 |
GenomicsPerformance of a Logistic Regression Model Using Paired miRNAs to Stratify Abnormal Mammograms for Benign Breast Lesions
Performance of a Logistic Regression Model Using Paired miRNAs to Stratify Abnormal Mammograms for Benign Breast Lesions
PRJNA1076088 | ENA
GenomicsLogistic regression for estimating functional effects with spatial transcriptomics
Logistic regression for estimating functional effects with spatial transcriptomics
PRJNA1425597 | ENA
ProteomicsThromboxane-A Synthase 1 as a Potential Dual Biomarker for Metastatic Prostate Cancer and Atherosclerosis: Insights from a Nanomedicine Protein Corona, Machine Learning, and Actual Causality Approaches
Prostate cancer (PC) is the most common cancer among men in the United States, while atherosclerosis (ASCVD) is the most prevalent cardiovascular disease (CVD) associated with it. CVD, particularly ASCVD, has been shown to contribute to metastatic prostate cancer (mPC) progression. Identifying blood...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD057863 | Pride
Protein corona Bottom up proteomics Machin learning Human plasma 
ProteomicsScreening of Serum Biomarkers for Coronary Artery Calcification Using DIA Quantitative Proteomics and Construction of a Regression Model
Abstract Background: Using DIA quantitative proteomics technology to screen for coronary artery calcification (CAC)-associated differentially expressed proteins, this study explores the value of SMOC1, HSP90B1, and OPTN as potential serum biomarkers for CAC and constructs an individualized risk pre...
ORGANISM(S): Homo Sapiens 
2026-03-07 | PXD075378 |
MetabolomicsUPLC-Q-TOF/MS-Based Plasma and Urine Metabolomics Contribute to the Diagnosis of Sepsis
In this study, we aimed to identify potential metabolic biomarkers that can improve the diagnostic accuracy of sepsis. Sixty-six patients including 30 septic and 36 nonsepsis patients from an intensive care unit were recruited. The global plasma and urine metabolomic profiles were determined by ultr...
2023-04-18 | MTBLS3505 | MetaboLights
TranscriptomicsMultiple Salivary Biomarkers for Early Detection of Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death. Lack of early detection technology for pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. Oral fluid (saliva) meets the demand for non-invasive, accessible, and highly efficie...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-14245 | biostudies-arrayexpress
GenomicsPerformance of a Logistic Regression Model Using Paired miRNAs to Stratify Abnormal Mammograms for Benign Breast Lesions
We have generated EarlyGuard™, a novel logistic regression model using five paired miRNAs, to stratify subjects with abnormal mammograms who are proven benign, i.e., neither a breast cancer nor a pre-cancerous diagnosis, on a subsequent diagnostic biopsy at NPV of 96.9%. The classifier could be used...
ORGANISM(S): Homo sapiens 
2026-03-01 | GSE255660 | GEO
TranscriptomicsRadiation induced gene signature predicts pathologic complete response to neoadjuvant chemotherapy in breast cancer patients
Purpose:The identification of biomarkers predictive of neoadjuvant chemotherapy response in breast cancer patients would be an important advancement in personalized cancer therapy. We hypothesized that due to similarities between radiation and chemotherapy induced cellular response mechanisms, radia...
ORGANISM(S): Mus musculus 
2015-01-21 | E-GEOD-48073 | biostudies-arrayexpress
TranscriptomicsSkeletal muscle gene expression in response to resistance exercise: sex specific regulation
The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exercise. We u...
ORGANISM(S): Homo sapiens 
2010-12-06 | E-GEOD-24235 | biostudies-arrayexpress
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